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Paula's Choice Clinical Niacinamide 20% Treatment

Clinical Niacinamide 20% Treatment

A highly concentrated niacinamide serum that effectively tightens and minimizes the look of sagging pores and rough bumps caused by age or sun damage.
Uploaded by: whishaw on

Highlights

#alcohol-free #fragrance & essentialoil-free #knownamountofactive
Alcohol Free
Fragrance and Essential Oil Free
Niacinamide: 20.0%

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Skim through

Ingredient name what-it-does irr., com. ID-Rating
Water (Aqua) solvent
Niacinamide cell-communicating ingredient, skin brightening, anti-acne, moisturizer/​humectant superstar
Pentylene Glycol (Solvent/Texture Enhancer) solvent, moisturizer/​humectant
Butylene Glycol (Slip Agent/Hydration) moisturizer/​humectant, solvent, viscosity controlling 0, 1
Glycerin (Skin-Replenishing) skin-identical ingredient, moisturizer/​humectant, perfuming, solvent, viscosity controlling 0, 0 superstar
Acetyl Glucosamine (Skin-Replenishing) skin-identical ingredient, skin brightening goodie
Ascorbyl Glucoside (Vitamin C/Antioxidant) antioxidant, skin brightening goodie
Glycyrrhiza Glabra (Licorice) Root Extract (Skinsoothing/Antioxidant) soothing, skin brightening superstar
Spiraea Ulmaria (Meadowsweet) Extract (Antioxidant) soothing goodie
Portulaca Oleracea (Purslane) Extract (Antioxidant) soothing, antioxidant goodie
Camellia Japonica Flower Extract (Antioxidant) emollient
Epigallocatechin Gallate (Green Tea-Derived Antioxidant) antioxidant, soothing superstar
Boerhavia Diffusa Root Extract (Skin-Soothing)
Camellia Sinensis (Green Tea) Leaf Extract (Antioxidant) antioxidant, soothing, antimicrobial/​antibacterial, emollient, moisturizer/​humectant superstar
Allantoin (Skinsoothing) soothing 0, 0 goodie
Lecithin (Skin-Replenishing) emollient, emulsifying goodie
Pullulan (Texture Enhancer)
Panthenol (Hydration) soothing, moisturizer/​humectant 0, 0 goodie
Silica (Absorbent) viscosity controlling
Xanthan Gum (Thickener) viscosity controlling, emulsifying, surfactant/​cleansing
Sclerotium Gum (Thickener) viscosity controlling
Propanediol (Hydration) solvent, moisturizer/​humectant
Sodium Phytate (Chelating Agent) chelating
Phenoxyethanol (Preservative) preservative
Ethylhexylglycerin (Preservative) preservative

Paula's Choice Clinical Niacinamide 20% Treatment
Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Niacinamide - superstar
Also-called: vitamin B3, nicotinamide | What-it-does: cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant
  • A multi-functional skincare superstar with several proven benefits for the skin
  • Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
  • Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
  • Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
  • Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Read all the geeky details about Niacinamide here >>

A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens. 

What-it-does: moisturizer/humectant, solvent, viscosity controlling | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

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It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant, perfuming, solvent, viscosity controlling | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

An amino acid sugar that can be found in the skin and does there good and important things. One of them is that it's a precursor for the biosynthesis of superstar moisturizer, hyaluronic acid. So acetyl glucosamine itself is also an important skin-identical ingredient and natural moisturizing factor.

But that is not all, acetyl glucosamine has two other great properties proved by double-blind clinical trials. First, it's a promising ingredient against wrinkles:  2% can improve wrinkles, particularly in the eye area.

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Second, the same amount can also fade - always stubborn - brown spots. (Do not expect magic, though - the photos from the study show the difference after 8 weeks of daily use. The difference is visible, but not that big. It's always good to have realistic expectations. :))  Combined with skincare superstar niacinamide the duo is synergistic and is more effective at improving hyperpigmentation, so if you are after the skin-lightening benefit look out for products that contain both. 

Also-called: Form of Vitamin C | What-it-does: antioxidant, skin brightening

A form of skincare superstar, vitamin C. If you do not know why vitamin C is such a big deal in skincare, we have a really detailed, geeky description that's good to read. :) 

So now you know that because pure vitamin C is such a diva (very unstable and hard to formulate) the cosmetic industry is trying to come up with some derivatives that have the badass anti-aging properties of vitamin C (antioxidant protection + collagen boosting + fading hyperpigmentation) but without the disadvantages. This is a hard task, and there is not yet a derivative that is really proven to be better in every aspect, but Ascorbyl Glucoside is one of the best options when it comes to vitamin C derivatives. Let's see why:

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First, it's really stable and easy to formulate, so the problems that come with pure vitamin C are solved here.

Second, in vitro (meaning made in the lab, not on real humans) studies show that ascorbyl glucoside can penetrate the skin. This is kind of important for an anti-aging ingredient to do the job, so this is good news, though in-vivo (made on real humans) studies are still needed. 

Third, in-vitro studies show that after ascorbyl glucoside is absorbed into the skin it is converted to pure vitamin C (though the rate of conversion is still a question mark). It also shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does

Bottom line: ascorbyl glucoside is one of the best and most promising vitamin C derivatives that shows similar benefits to that of pure vitamin C, but it's less proven (in vivo vs. in vitro studies) and the extent of the benefits are also not the same.  

Also-called: Licorice Root;Glycyrrhiza Glabra Root Extract | What-it-does: soothing, skin brightening

You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. It's sweet and yellow and not only used for licorice all sorts but it's also a skincare superstar thanks to two magic properties:

Nr. 1 magic property is that it has skin-lightening or to say it another way depigmenting properties. The most active part is called glabridin. The topical application (meaning when you put it on your face) of 0.5% glabridin was shown to inhibit UVB caused pigmentation of guinea pigs. Another study even suggested that licorice is more effective than the gold standard skin-lightening agent hydroquinone. All in all, licorice is considered to be one of the safest skin lightening agents with the fewest side effects.

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There is just one catch regarding glabridin and licorice: the amount of glabridin in commercial licorice extracts can vary a lot. We have seen extracts with only 4% glabridin as well as 40% glabridin. The latter one is a very-very expensive ingredient, so if you are after the depigmenting properties try to choose a product that boasts its high-quality licorice extract. 

Nr. 2 magic property is that licorice is a potent anti-inflammatory. Glabridin has also some soothing properties but the main active anti-inflammatory component is glycyrrhizin. It’s used to treat several skin diseases that are connected to inflammation including atopic dermatitis, rosacea or eczema. 

Oh, and one more thing: glabridin seems to be also an antioxidant, which is just one more reason to be happy about licorice root extract on an ingredient list. 

Bottom line: Licorice is a great skincare ingredient with significant depigmenting, anti-inflammatory and even some antioxidant properties. Be happy if it's on the ingredient list. :)

Also-called: Meadowsweet Extract, Filipendula Ulmaria Extract | What-it-does: soothing, astringent

The extract coming from the leaves and/or blossoms of Meadowsweet, a native to Europe plant that likes to grow in damp places such as meadows or the banks of streams.

It's main "skincare thing" is that it contains salicylic acid derivatives that give the extract anti-inflammatory properties. It also has tannins that make Spiraea Ulmaria Extract astringent, as well as spiraeoside that has anti-cellulitic properties.

Also-called: Purslane Extract | What-it-does: soothing, antioxidant

Portulaca Oleracea is a nice succulent with bright yellow flowers and edible nutritious vegetables. It's a famous plant in Korean traditional medicine to treat infection and irritated skin.

Modern research confirms that it's loaded with skin-goodies: it's the richest green plant source of omega-3 fatty acids (α-linolenic acid), contains NMFs (polysaccharides and amino acids),  vitamins (β-carotene), minerals, and antioxidants (yellow betaxanthins and reddish betacyanins). Thanks to all its beneficial components, Purslane Extract has several magic properties: it's a great anti-inflammatory and antioxidant agent and also has wound healing abilities

What-it-does: emollient

We don't have description for this ingredient yet.

Also-called: EGCG | What-it-does: antioxidant, soothing

If EGCG does not tell you anything, green tea sure does. We have written about green tea in excruciating details, so if you wanna become an expert in the "green tea in skincare" topic,  click here and read it

So now you know that EGCG is the magic ingredient in green tea. It's the most active polyphenol that green tea owes most of its magic properties to. It's a fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. Be happy, if you spot it on the ingredient list. 

We don't have description for this ingredient yet.

  • Green tea is one of the most researched natural ingredients
  • The active parts are called polyphenols, or more precisely catechins (EGCG being the most abundant and most active catechin)
  • There can be huge quality differences between green tea extracts. The good ones contain 50-90% catechins (and often make the product brown and give it a distinctive smell)
  • Green tea is proven to be a great antioxidant, UV protectant, anti-inflammatory, anticarcinogenic and antimicrobial
  • Because of these awesome properties green tea is a great choice for anti-aging and also for skin diseases including rosacea, acne and atopic dermatitis
Read all the geeky details about Camellia Sinensis Leaf Extract here >>

What-it-does: soothing | Irritancy: 0 | Comedogenicity: 0

Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. 

It's not only soothing but it' also skin-softening and protecting and can promote wound healing.

What-it-does: emollient, emulsifying

A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes

If you ever wondered what those little Listerine breath strips were made of, you found your answer! Pullulan is a polysaccharide polymer, which basically means that it’s a big molecule made up of smaller sugar molecule units.

It dissolves in water and can make a thin, elastic, and moisture-absorbing film when spread on the skin that can cause an instant tightening effect. It can also be used as a thickener to get a silicone-like feel and can be used in peel-off masks. Btw, it's made from fungus via fermentation. 

Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

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Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.

Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. 

If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.

As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily. 

A white powdery thing that's the major component of glass and sand. In cosmetics, it’s often in products that are supposed to keep your skin matte as it has great oil-absorbing abilities. It’s also used as a helper ingredient to thicken up products or suspend insoluble particles. 

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

A big sugar molecule (polysaccharide) that is used as a natural thickening and gelling agent. It is similar to more commonly used Xanthan Gum, and the two are also often combined to create gel formulas or to stabilize emulsions. 

Also-called: Zemea | What-it-does: solvent, moisturizer/humectant

Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved. 

It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula. 

What-it-does: chelating

It’s one of those little helper ingredients that makes sure the product stays the same over time. No color change or anything like that. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. 

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

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Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
what‑it‑does solvent | moisturizer/humectant
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent, and a broad spectrum antimicrobial. [more]
what‑it‑does moisturizer/humectant | solvent | viscosity controlling
irritancy, com. 0, 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant | perfuming | solvent | viscosity controlling
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does skin-identical ingredient | skin brightening
An amino sugar that helps the skin to stay hydrated, is also promising against wrinkles and can help to fade brown spots particularly when combined with niacinamide. [more]
what‑it‑does antioxidant | skin brightening
A stable and easy to formulate form of skincare superstar, vitamin C. In-vitro studies show that it shows all the three anti-aging benefits (antioxidant protection + collagen boosting + fading hyperpigmentation) that pure vitamin C does. [more]
what‑it‑does soothing | skin brightening
You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. [more]
what‑it‑does soothing
The extract of Meadowsweet that has anti-inflammatory, astringent and anti-cellulitic properties. [more]
what‑it‑does soothing | antioxidant
Purslane Extract - a traditional Korean medicinal plant with skin-soothing, antioxidant and wound healing abilities. [more]
what‑it‑does emollient
what‑it‑does antioxidant | soothing
The most active polyphenol in green tea. A fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. [more]
what‑it‑does antioxidant | soothing | antimicrobial/antibacterial | emollient | moisturizer/humectant
Green Tea - one of the most researched natural ingredients that contains the superstar actives called catechins. It has proven antioxidant, anti-inflammatory, antimicrobial and anticarcinogenic properties. [more]
what‑it‑does soothing
irritancy, com. 0, 0
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically. It's not only soothing but it' [more]
what‑it‑does emollient | emulsifying
It's quite the multi-tasker: an emollient and water-binding ingredient but also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.  [more]
If you ever wondered what those little Listerine breath strips were made of, you found your answer! Pullulan is a polysaccharide polymer, which basically means that it’s a big molecule made up of smaller sugar molecule units. It dissolves in water and can make a thin, elastic, and moisture-absorbing film when spread on the skin that can cause an instant tightening effect. [more]
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0, 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
what‑it‑does viscosity controlling
A white powdery thing that can mattify the skin and thicken up cosmetic products. [more]
what‑it‑does viscosity controlling | emulsifying | surfactant/cleansing
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does viscosity controlling
A big sugar molecule (polysaccharide) that is used as a natural thickening and gelling agent. It is similar to more commonly used Xanthan Gum, and the two are also often combined to create gel formulas or to stabilize emulsions.  [more]
what‑it‑does solvent | moisturizer/humectant
A natural corn sugar derived glycol. It can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula. [more]
what‑it‑does chelating
It’s one of those little helper ingredients that makes sure the product stays the same over time. No color change or anything like that. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.  [more]
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]