Dermedic Hydrain 3 Hialuro Cream
Dermedic

Hydrain 3 Hialuro Cream

Provides intensive, in-depth and long-lasting hydration which can be felt 48 hours after application. Replenishes moisture in the skin and limits the transepidermal water loss
Uploaded by: cosmofeya on 27/09/2018

Ingredients overview

Aqua
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
,
Caprylic/​Capric Triglyceride
what‑it‑does emollient
A very common emollient that makes your skin feel nice and smooth. Comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. [more]
,
Urea
what‑it‑does skin-identical ingredient | moisturizer/humectant
The thing in the pee that is also a natural moisturizing factor (NMF) with mild keratolytic and strong skin moisturizing superpowers. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Methylpropanediol
what‑it‑does solvent
A type of glycol. Its main job is to be a solvent, but it has also very good antimicrobial properties and acts as a true preservative booster. [more]
,
Isocetyl Stearate
what‑it‑does emollient
com. 1
A clear pale yellow oily liquid (an ester) that makes your skin feel nice and smooth, aka emollient. It has a rich, but non-greasy skin-feel, and can provide a mild feel to the products.
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Betaine
what‑it‑does moisturizer/humectant
A sugar beet derived amino acid derivative with nice skin protection and moisturization properties. Its special thing is being an osmolyte, a molecule that helps to control cell-water balance.  [more]
,
Cetyl Alcohol
what‑it‑does emollient | emulsifying | viscosity controlling
irritancy, com. 2 2
A fatty (the good, non-drying kind of) alcohol that makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier).
, [more]
Squalane
what‑it‑does skin-identical ingredient | emollient
irritancy, com. 0 1
An emollient and natural moisturizer that can be found also in the sebum (oily stuff our skin produces). It leaves a nice non-greasy, non-heavy feeling on the skin. [more]
,
Tocopheryl Acetate
what‑it‑does antioxidant
irritancy, com. 0 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
,
Polyacrylamide
what‑it‑does viscosity controlling
A film-forming and thickening polymer (a large molecule composed of many repeated subunits) that comes to the formula usually as part of an emulsifier, thickener trio. [more]
,
C13-14 Isoparaffin
what‑it‑does emollient | viscosity controlling
A petroleum-derived emollient and thickener. It often comes to the formula as part of an emulsifier, thickener trio. [more]
,
Laureth-7
what‑it‑does emulsifying | surfactant/cleansing
A not-very-interesting helper ingredient that is used as an emulsifier and/or surfactant. Comes from a coconut oil derived fatty alcohol, lauryl alcohol. [more]
,
Acrylates /​ C10-30 Alkyl Acrylate Crosspolymer
what‑it‑does viscosity controlling
A common helper ingredient that stabilizes emulsions and helps to thicken up products. [more]
,
Triethanolamine
what‑it‑does buffering | emulsifying | surfactant/cleansing
irritancy, com. 0 2
Helps to set the pH of a cosmetic formulation to be right. It’s very alkaline. [more]
,
Dmdm Hydantoin
what‑it‑does preservative
A controversial preservative that has formaldehyde-releasing properties. It works great against bacteria and also has mild fungicide abilities.  [more]
,
Iodopropynyl Butylcarbamate
what‑it‑does preservative
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. Its strong point is being effective against yeasts and molds, and as a nice bonus seems to be non-comedogenic as well.It is safe in concentrations of less than 0.1% but is acutely toxic when inhaled, so it's not the proper preservative choice for aerosol formulas like hairsprays. [more]
,
Parfum
what‑it‑does perfuming
The generic term for nice smelling stuff put into cosmetic products so that the end product also smells nice. It is made up of 30 to 50 chemicals on average. [more]
,
Ci 42090
what‑it‑does colorant
Synthetic colorant with smurf-like blue color. [more]
[less]

Highlights

Key Ingredients

Antioxidant: Tocopheryl Acetate
what‑it‑does antioxidant
irritancy, com. 0 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
Skin-identical ingredient: Urea
what‑it‑does skin-identical ingredient | moisturizer/humectant
The thing in the pee that is also a natural moisturizing factor (NMF) with mild keratolytic and strong skin moisturizing superpowers. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Squalane
what‑it‑does skin-identical ingredient | emollient
irritancy, com. 0 1
An emollient and natural moisturizer that can be found also in the sebum (oily stuff our skin produces). It leaves a nice non-greasy, non-heavy feeling on the skin. [more]

Show all ingredients by function

Other Ingredients

Buffering: Triethanolamine
what‑it‑does buffering | emulsifying | surfactant/cleansing
irritancy, com. 0 2
Helps to set the pH of a cosmetic formulation to be right. It’s very alkaline. [more]
Colorant: Ci 42090
what‑it‑does colorant
Synthetic colorant with smurf-like blue color. [more]
Emollient: Caprylic/​Capric Triglyceride
what‑it‑does emollient
A very common emollient that makes your skin feel nice and smooth. Comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. [more]
,
Isocetyl Stearate
what‑it‑does emollient
com. 1
A clear pale yellow oily liquid (an ester) that makes your skin feel nice and smooth, aka emollient. It has a rich, but non-greasy skin-feel, and can provide a mild feel to the products.
,
Cetyl Alcohol
what‑it‑does emollient | emulsifying | viscosity controlling
irritancy, com. 2 2
A fatty (the good, non-drying kind of) alcohol that makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier).
,
Squalane
what‑it‑does skin-identical ingredient | emollient
irritancy, com. 0 1
An emollient and natural moisturizer that can be found also in the sebum (oily stuff our skin produces). It leaves a nice non-greasy, non-heavy feeling on the skin. [more]
,
C13-14 Isoparaffin
what‑it‑does emollient | viscosity controlling
A petroleum-derived emollient and thickener. It often comes to the formula as part of an emulsifier, thickener trio. [more]
Emulsifying: Cetyl Alcohol
what‑it‑does emollient | emulsifying | viscosity controlling
irritancy, com. 2 2
A fatty (the good, non-drying kind of) alcohol that makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier).
,
Laureth-7
what‑it‑does emulsifying | surfactant/cleansing
A not-very-interesting helper ingredient that is used as an emulsifier and/or surfactant. Comes from a coconut oil derived fatty alcohol, lauryl alcohol. [more]
,
Triethanolamine
what‑it‑does buffering | emulsifying | surfactant/cleansing
irritancy, com. 0 2
Helps to set the pH of a cosmetic formulation to be right. It’s very alkaline. [more]
Moisturizer/humectant: Urea
what‑it‑does skin-identical ingredient | moisturizer/humectant
The thing in the pee that is also a natural moisturizing factor (NMF) with mild keratolytic and strong skin moisturizing superpowers. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Betaine
what‑it‑does moisturizer/humectant
A sugar beet derived amino acid derivative with nice skin protection and moisturization properties. Its special thing is being an osmolyte, a molecule that helps to control cell-water balance.  [more]
Perfuming: Parfum
what‑it‑does perfuming
The generic term for nice smelling stuff put into cosmetic products so that the end product also smells nice. It is made up of 30 to 50 chemicals on average. [more]
Preservative: Dmdm Hydantoin
what‑it‑does preservative
A controversial preservative that has formaldehyde-releasing properties. It works great against bacteria and also has mild fungicide abilities.  [more]
,
Iodopropynyl Butylcarbamate
what‑it‑does preservative
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. Its strong point is being effective against yeasts and molds, and as a nice bonus seems to be non-comedogenic as well.It is safe in concentrations of less than 0.1% but is acutely toxic when inhaled, so it's not the proper preservative choice for aerosol formulas like hairsprays. [more]
Solvent: Aqua
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
,
Methylpropanediol
what‑it‑does solvent
A type of glycol. Its main job is to be a solvent, but it has also very good antimicrobial properties and acts as a true preservative booster. [more]
Surfactant/cleansing: Laureth-7
what‑it‑does emulsifying | surfactant/cleansing
A not-very-interesting helper ingredient that is used as an emulsifier and/or surfactant. Comes from a coconut oil derived fatty alcohol, lauryl alcohol. [more]
,
Triethanolamine
what‑it‑does buffering | emulsifying | surfactant/cleansing
irritancy, com. 0 2
Helps to set the pH of a cosmetic formulation to be right. It’s very alkaline. [more]
Viscosity controlling: Cetyl Alcohol
what‑it‑does emollient | emulsifying | viscosity controlling
irritancy, com. 2 2
A fatty (the good, non-drying kind of) alcohol that makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier).
,
Polyacrylamide
what‑it‑does viscosity controlling
A film-forming and thickening polymer (a large molecule composed of many repeated subunits) that comes to the formula usually as part of an emulsifier, thickener trio. [more]
,
C13-14 Isoparaffin
what‑it‑does emollient | viscosity controlling
A petroleum-derived emollient and thickener. It often comes to the formula as part of an emulsifier, thickener trio. [more]
,
Acrylates /​ C10-30 Alkyl Acrylate Crosspolymer
what‑it‑does viscosity controlling
A common helper ingredient that stabilizes emulsions and helps to thicken up products. [more]

Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

What-it-does: emollient

A very common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, and it’s also easy to formulate with. No wonder it’s popular. 

Urea - goodie
Also-called: Carbamide | What-it-does: skin-identical ingredient, moisturizer/humectant

Yes, it's the thing that can be found naturally in pee. And in the skin. It is an awesome natural moisturizing factor, aka NMF.  NMFs are important components that help the skin to hold onto water and keep it plump, elastic and hydrated. Urea makes up about 7% of NMFs next to other things such as amino acids (40%), PCA (12%) or Lactate (12%).

What makes urea special, is that it is not only a simple moisturizer, but it is thought to be a "small-molecule regulator of epidermal structure and function" meaning that it has a bunch of extra biological activities. It acts as a mild keratolytic agent (some of its moisturizing action is thought to come from urea's ability to break down bonds in the protein called filaggrin and thus freeing up amino acids in the skin), enhances antimicrobial peptide expression and improves skin barrier function

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Being a mild keratolytic agent and strong moisturizer means that high-percentage (10-40%) urea treatments are found effective in a bunch of skin disorders connected to excessive dryness and malfunctioning skin barrier such as ichthyosis, xerosis, psoriasis, eczema and seborrheic dermatitis.  

Overall, just like glycerin, urea is a real oldie but a goodie, a nice ingredient in any moisturizer.

Glycerin - goodie
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • Super common, used for more than 50 years
  • Not only a simple moisturizer but plays an important role in keeping the stuff between our skin cells healthy
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: solvent

It's a type of glycol that - according to the manufacturer - is an extremely good replacement for other glycols like propylene or butylene glycol. Its main job is to be a solvent, but it has also very good antimicrobial properties and acts as a true preservative booster. Also helps with skin hydration without stickiness or tacky feel.

What-it-does: emollient | Comedogenicity: 1

A clear pale yellow oily liquid (an ester) that makes your skin feel nice and smooth, aka emollient. It has a rich, but non-greasy skin-feel, and can provide a mild feel to the products.

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Betaine - goodie
What-it-does: moisturizer/humectant

A sugar beet derived amino acid derivative with nice skin protection and moisturization properties. Betain's special thing is being an osmolyte, a molecule that helps to control cell-water balance.  It is also a natural osmoprotectant, meaning that it attracts water away from the protein surface and thus protects them from denaturation and increases their thermodynamic stability. 

It also gives sensorial benefits to the formula and when used in cleansers, it helps to make them milder and gentler. 

What-it-does: emollient, emulsifying, viscosity controlling | Irritancy: 2 | Comedogenicity: 2

A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.

Squalane - goodie
What-it-does: skin-identical ingredient, emollient | Irritancy: 0 | Comedogenicity: 1

It seems to us that squalane is in fashion and there is a reason for it. Chemically speaking, it is a saturated  (no double bonds) hydrocarbon (a molecule consisting only of carbon and hydrogen), meaning that it's a nice and stable oily liquid with a long shelf life. 

It occurs naturally in certain fish and plant oils (e.g. olive), and in the sebum (the oily stuff our skin produces) of the human skin. As f.c. puts it in his awesome blog post, squalane's main things are "emolliency, surface occlusion, and TEWL prevention all with extreme cosmetic elegance". In other words, it's a superb moisturizer that makes your skin nice and smooth, without being heavy or greasy.

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Another advantage of squalane is that it is pretty much compatible with all skin types and skin conditions. It is excellent for acne-prone skin and safe to use even if you have fungi-related skin issues, like seborrhea or fungal acne.

The unsaturated (with double bonds) and hence less stable version of Squalane is Squalene, you can read about it here >> 

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

What-it-does: viscosity controlling

It's a film-forming and thickening polymer (a large molecule composed of many repeated subunits) that comes to the formula usually as part of an emulsifier, thickener trio (with C13-14 Isoparaffin and Laureth-7, trade named Sepigel 305). This trio is an easy-to-use liquid that helps to create nice, non-tacky gel formulas

It's a petroleum derived emollient and thickener. It often comes to the formula as part of an emulsifier, thickener trio (with Polyacrylamide and Laureth-7). This trio is an easy-to-use liquid that helps to create nice, non-tacky gel formulas. 

A not-very-interesting helper ingredient that is used as an emulsifier and/or surfactant. Comes from a coconut oil derived fatty alcohol, lauryl alcohol.

Though its long name does not reveal it, this polymer molecule (big molecule from repeated subunits or monomers) is a relative to the super common, water-loving thickener, Carbomer. Both of them are big molecules that contain acrylic acid units, but Acrylates/C10-30 Alkyl Acrylate Crosspolymer also contains some other monomers that are hydrophobic, i.e. water-hating. 

This means that our molecule is part water- and part oil-loving, so it not only works as a thickener but also as an emulsion stabilizer. It is very common in gel-type formulas that also contain an oil-phase as well as in cleansers as it also works with most cleansing agents (unlike a lot of other thickeners). 

What-it-does: buffering, emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 2

It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right. It’s very alkaline (you know the opposite of being very acidic): a 1% solution has a pH of around 10.

It does not have the very best safety reputation but in general, you do not have to worry about it. 

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What is true is that if a product contains so-called N-nitrogenating agents (e.g.: preservatives like 2-Bromo-2-Nitropropane-1,3-Diol, 5-Bromo-5-Nitro- 1,3-Dioxane or sodium nitrate - so look out for things with nitro, nitra in the name) that together with TEA can form some not nice carcinogenic stuff (that is called nitrosamines). But with proper formulation that does not happen, TEA in itself is not a bad guy. 

But let’s assume a bad combination of ingredients were used and the nitrosamines formed. :( Even in that case you are probably fine because as far as we know it cannot penetrate the skin. 

But to be on the safe side, if you see Triethanolamine in an INCI and also something with nitra, nitro in the name of it just skip the product, that cannot hurt.

What-it-does: preservative

A controversial preservative that has formaldehyde-releasing properties. It works great against bacteria and also has mild fungicide abilities. 

Cosmetic chemist, Colin wrote a great article about formaldehyde and DMDM Hydantoin.  He writes that formaldehyde is the perfect example of "the dose makes the poison" principle. It's a natural stuff that can also be found in fresh fruits and vegetables, and eating it in tiny amounts is totally ok. However, in larger amounts (according to Wikipedia 30 mL of a solution containing 37% formaldehyde) it's deadly. 

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The amount of formaldehyde used in cosmetics either neat or through formaldehyde-releasing preservatives is tiny. Probably that is why the Cosmetic Ingredient Review Broad concluded both in 1988 and in 2008 that DMDM Hydantoin is "safe as used in cosmetics".

However, Colins argues that in the case of formaldehyde-releasing preservatives, formaldehyde is released slowly and the skin has probably not evolved to deal with that. The lingering formaldehyde might be toxic to the Langerhans Cells that are important for the skin's defense system. Another potential issue is that formaldehyde-releasers might also release other things while reacting with amino acids in the skin that is probably the explanation why some people are not allergic to formaldehyde but are allergic to formaldehyde-releasing preservatives. These are all theories, far from proven facts, but we feel that there are some justified reasons why formaldehyde-releasing preservatives and Dmdm Hydantoin count as controversial. 

All in all, it's up to you to decide if you wanna avoid this preservative group or not. If so, there are other, less risky and more skin-friendly options out there.

What-it-does: preservative

It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. Its strong point is being effective against yeasts and molds, and as a nice bonus seems to be non-comedogenic as well.

It is safe in concentrations of less than 0.1% but is acutely toxic when inhaled, so it's not the proper preservative choice for aerosol formulas like hairsprays. Used at 0.1%, Iodopropynyl Butylcarbamate has an extremely low rate of skin-irritation when applied directly for 24 hours (around 0.1% of 4,883 participants) and after 48 hours that figure was 0.5%, so it counts as mild and safe unless your skin is super-duper sensitive.

Parfum - icky
Also-called: Fragrance, Parfum | What-it-does: perfuming

Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!). 

If you are someone who likes to know what you put on your face than fragrance is not your best friend - no way to know what’s really in it.  

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Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!). 

Also-called: Blue 1 | What-it-does: colorant

CI 42090 or Blue 1 is a super common synthetic colorant in beauty & food. Used alone, it adds a brilliant smurf-like blue color, combined with Tartrazine, it gives the fifty shades of green.

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