Manyo Factory Bifidalacto Complex
Manyo Factory

Bifidalacto Complex

Bifidalacto Complex is a magic anti-aging essence that in 90% consists of Bifidobacteria and Lactobacilli enzymes, Adenosine, Galactomyces and Niacinamide
Uploaded by: dstandal on 26/04/2018

Ingredients overview

Bifida Ferment Lysate
A probiotic ingredient that might protect against UV-induced damage, help barrier repair and decrease skin sensitivity. [more]
,
Lactobacillus/Pumpkin Fruit Ferment Filtrate, Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
,
Butylene Glycol
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
,
Copper Tripeptide-1
what‑it‑does cell-communicating ingredient | soothing | antioxidant
A copper-peptide complex that has unique wound healing and skin remodelling properties. It's also an anti-inflammatory and antioxidant agent. [more]
,
Aureobasidium Pullulans Ferment, Panax Ginseng Callus Culture Extract, Zanthoxylum Piperitum Fruit Extract
what‑it‑does antioxidant | antimicrobial/antibacterial | preservative
Japanese pepper extract that has natural antibacterial and preservative activities. Combined with Usnea Barbata and Pulsatilla Koreana, it is part of a popular Korean preservative system called EURO-NApre. [more]
,
Pulsatilla Koreana Extract
what‑it‑does antimicrobial/antibacterial | preservative
The extract of Korean Pasque Flower that is mostly used for its antimicrobial and natural preservative activities. It usually comes to the formula combined with Zanthoxylum Piperitum and Usnea Barbata, as the three extracts make up a popular Korean natural preservative system trade named EURO-NApre.  [more]
, [more]
Usnea Barbata (Lichen) Extract
what‑it‑does preservative | antimicrobial/antibacterial
The extract coming from the alpine lichen, Usnea Barbata. It is known for its excellent efficacy against gram-positive bacteria, meaning that it can serve as a natural preservative and deodorant agent.Its main biologically active component is usnic acid (a molecule produced only by lichens) that's not only an antibacterial agent, but also has antioxidant, anti-inflammatory and wound-h [more]
,
Acetyl Hexapeptide-8
what‑it‑does cell-communicating ingredient | moisturizer/humectant
Argireline - famous peptide that's often referred to as "Botox in a jar". In reality, it's nowhere near that powerful, but it can smooth wrinkles to some extent by preventing facial muscles from contracting. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Physalis Alkekengi Fruit Extract, Caffeine
what‑it‑does antioxidant
The well-known stimulant from coffee. It has nice antioxidant properties and can improve the microcirculation. Might be helpful for dark circles, puffy eyes, as well as cellulite and hair loss. [more]
,
Hydrolyzed Algin, Red Ginseng Extract
what‑it‑does antioxidant
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Adenosine
what‑it‑does cell-communicating ingredient
An important compound in our body that has a vital cell-signalling role. It is wound healing, anti-inflammatory and can help with barrier repair. [more]
,
Methyl Gluceth-20
what‑it‑does moisturizer/humectant
A corn sugar-derived, water-soluble, pale yellow syrup, that nicely moisturizes the skin. It has a light and smooth skin feel. [more]
,
Epigallocatechin Gallate
what‑it‑does antioxidant | soothing
The most active polyphenol in green tea. A fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. [more]
[less]

Highlights

Key Ingredients

Anti-acne: Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
Antioxidant: Copper Tripeptide-1
what‑it‑does cell-communicating ingredient | soothing | antioxidant
A copper-peptide complex that has unique wound healing and skin remodelling properties. It's also an anti-inflammatory and antioxidant agent. [more]
,
Zanthoxylum Piperitum Fruit Extract
what‑it‑does antioxidant | antimicrobial/antibacterial | preservative
Japanese pepper extract that has natural antibacterial and preservative activities. Combined with Usnea Barbata and Pulsatilla Koreana, it is part of a popular Korean preservative system called EURO-NApre. [more]
,
Caffeine
what‑it‑does antioxidant
The well-known stimulant from coffee. It has nice antioxidant properties and can improve the microcirculation. Might be helpful for dark circles, puffy eyes, as well as cellulite and hair loss. [more]
,
Red Ginseng Extract
what‑it‑does antioxidant
,
Epigallocatechin Gallate
what‑it‑does antioxidant | soothing
The most active polyphenol in green tea. A fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. [more]
Cell-communicating ingredient: Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
,
Copper Tripeptide-1
what‑it‑does cell-communicating ingredient | soothing | antioxidant
A copper-peptide complex that has unique wound healing and skin remodelling properties. It's also an anti-inflammatory and antioxidant agent. [more]
,
Acetyl Hexapeptide-8
what‑it‑does cell-communicating ingredient | moisturizer/humectant
Argireline - famous peptide that's often referred to as "Botox in a jar". In reality, it's nowhere near that powerful, but it can smooth wrinkles to some extent by preventing facial muscles from contracting. [more]
,
Adenosine
what‑it‑does cell-communicating ingredient
An important compound in our body that has a vital cell-signalling role. It is wound healing, anti-inflammatory and can help with barrier repair. [more]
Skin brightening: Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
Skin-identical ingredient: Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
Soothing: Copper Tripeptide-1
what‑it‑does cell-communicating ingredient | soothing | antioxidant
A copper-peptide complex that has unique wound healing and skin remodelling properties. It's also an anti-inflammatory and antioxidant agent. [more]
,
Epigallocatechin Gallate
what‑it‑does antioxidant | soothing
The most active polyphenol in green tea. A fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. [more]

Show all ingredients by function

Other Ingredients

Antimicrobial/antibacterial: Zanthoxylum Piperitum Fruit Extract
what‑it‑does antioxidant | antimicrobial/antibacterial | preservative
Japanese pepper extract that has natural antibacterial and preservative activities. Combined with Usnea Barbata and Pulsatilla Koreana, it is part of a popular Korean preservative system called EURO-NApre. [more]
,
Pulsatilla Koreana Extract
what‑it‑does antimicrobial/antibacterial | preservative
The extract of Korean Pasque Flower that is mostly used for its antimicrobial and natural preservative activities. It usually comes to the formula combined with Zanthoxylum Piperitum and Usnea Barbata, as the three extracts make up a popular Korean natural preservative system trade named EURO-NApre.  [more]
,
Usnea Barbata (Lichen) Extract
what‑it‑does preservative | antimicrobial/antibacterial
The extract coming from the alpine lichen, Usnea Barbata. It is known for its excellent efficacy against gram-positive bacteria, meaning that it can serve as a natural preservative and deodorant agent.Its main biologically active component is usnic acid (a molecule produced only by lichens) that's not only an antibacterial agent, but also has antioxidant, anti-inflammatory and wound-h [more]
Moisturizer/humectant: Niacinamide
what‑it‑does cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant
A multi-functional skincare superstar that has clinically proven anti-aging, skin lightening, anti-inflammatory and barrier repair properties. [more]
,
Butylene Glycol
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]
,
Acetyl Hexapeptide-8
what‑it‑does cell-communicating ingredient | moisturizer/humectant
Argireline - famous peptide that's often referred to as "Botox in a jar". In reality, it's nowhere near that powerful, but it can smooth wrinkles to some extent by preventing facial muscles from contracting. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Sodium Hyaluronate
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
,
Methyl Gluceth-20
what‑it‑does moisturizer/humectant
A corn sugar-derived, water-soluble, pale yellow syrup, that nicely moisturizes the skin. It has a light and smooth skin feel. [more]
Preservative: Zanthoxylum Piperitum Fruit Extract
what‑it‑does antioxidant | antimicrobial/antibacterial | preservative
Japanese pepper extract that has natural antibacterial and preservative activities. Combined with Usnea Barbata and Pulsatilla Koreana, it is part of a popular Korean preservative system called EURO-NApre. [more]
,
Pulsatilla Koreana Extract
what‑it‑does antimicrobial/antibacterial | preservative
The extract of Korean Pasque Flower that is mostly used for its antimicrobial and natural preservative activities. It usually comes to the formula combined with Zanthoxylum Piperitum and Usnea Barbata, as the three extracts make up a popular Korean natural preservative system trade named EURO-NApre.  [more]
,
Usnea Barbata (Lichen) Extract
what‑it‑does preservative | antimicrobial/antibacterial
The extract coming from the alpine lichen, Usnea Barbata. It is known for its excellent efficacy against gram-positive bacteria, meaning that it can serve as a natural preservative and deodorant agent.Its main biologically active component is usnic acid (a molecule produced only by lichens) that's not only an antibacterial agent, but also has antioxidant, anti-inflammatory and wound-h [more]
Solvent: Butylene Glycol
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0 1
An often used glycol that works as a solvent, humectant, penetration enhancer and also gives a good slip to the products. [more]

Ingredients explained

It’s a probiotic ingredient that’s used in one of the most iconic serums in the world, the Estee Lauder Advanced Night Repair.

Based on manufacturer info it potently protects against UV-induced damage in the skin and helps with DNA repair. An Estee Lauder patent from 2009 also talks about DNA repair activity.

Expand to read more

As far as published research goes we could find one promising one. It showed that applying 10% bacterial extract to sensitive, reactive skin helped with better barrier function and decreased skin sensitivity

So all in all: definitely a promising ingredient, even for sensitive skin types but not the most proven one (yet).

We don't have description for this ingredient yet.

Niacinamide - superstar
Also-called: vitamin B3, nicotinamide | What-it-does: cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant
  • A multi-functional skincare superstar with several proven benefits for the skin
  • Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
  • Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
  • Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
  • Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Read all the geeky details about Niacinamide here >>

What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 1

Butylene glycol, or let’s just call it BG, is a multi-tasking colorless, syrupy liquid. It’s a great pick for creating a nice feeling product.  

BG’s main job is usually to be a solvent for the other ingredients. Other tasks include helping the product to absorb faster and deeper into the skin (penetration enhancer), making the product spread nicely over the skin (slip agent), and attracting water (humectant) into the skin.

Expand to read more

It’s an ingredient whose safety hasn’t been questioned so far by anyone (at least not that we know about). BG is approved by Ecocert and is also used enthusiastically in natural products. BTW, it’s also a food additive. 

Also-called: GHK-Cu | What-it-does: cell-communicating ingredient, soothing, antioxidant
  • GHK-Cu is a copper-peptide complex found naturally in yucky bodily fluids (plasma, saliva, and urine)
  • It has unique wound healing properties by stimulating the breakdown of unhealthy, too large collagen in scar tissue and stimulating nice and healthy collagen production afterwards
  • It stimulates the production of several important skin-identical ingredients (e.g. collagen, elastin, and glycosaminoglycans)
  • It has significant anti-inflammatory and antioxidant effect
  • There are a few promising studies showing GHK-Cu can improve skin elasticity, clarity, firmness and reduce lines and wrinkles
  • It can improve hair growth by enlarging hair follicles (and bigger follicles produce longer, thicker hair)
  • There are some urban legends about possible overdosing or facial hair problems (read more in geeky details)
Read all the geeky details about Copper Tripeptide-1 here >>

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Also-called: Japanese Pepper, Korean Pepper, Sanshō, Chopi | What-it-does: antioxidant, antimicrobial/antibacterial, preservative

If you are into Japanese cuisine, you might know this guy as Japanese pepper or Sanshō pepper that is known for its unique fresh aroma and appetite increasing spicy sensation.

As for the skin benefits of Zanthoxylum Piperitum, it might have antioxidant effects (with active components called hyperoside and quercitrin), but more importantly, it is an antibacterial and natural preservative agent. It is pretty common in K-Beauty products, as it's one of the three natural extracts that make up the popular Korean preservative called EURO-NApre. 

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Combined with Usnea Barbata and Pulsatilla Koreana, these three extracts are claimed to form a natural preservative system that also has anti-inflammatory effects and might help with skin conditions such as blemishes, atopic dermatitis, and dandruff. 

On the flip side, Zanthoxylum Piperitum contains fragrant components (Limonene and Citrone), that might irritate sensitive skin. 

Also-called: Korean Pasque Flower Extract | What-it-does: antimicrobial/antibacterial, preservative

The extract of Korean Pasque Flower that is mostly used for its antimicrobial and natural preservative activities. It usually comes to the formula combined with Zanthoxylum Piperitum and Usnea Barbata, as the three extracts make up a popular Korean natural preservative system trade named EURO-NApre.  

The plant extract is also a traditional oriental herbal medicine that is known for its analgesic, anti-inflammatory, and astringent effects. 

Also-called: Lichen Extract | What-it-does: preservative, antimicrobial/antibacterial, deodorant

The extract coming from the alpine lichen, Usnea Barbata. It is known for its excellent efficacy against gram-positive bacteria, meaning that it can serve as a natural preservative and deodorant agent.

Its main biologically active component is usnic acid (a molecule produced only by lichens) that's not only an antibacterial agent, but also has antioxidant, anti-inflammatory and wound-healing promoting effects. According to manufacturer info,  the antibacterial activity of Usnea Barbata makes the ingredient helpful against body odor, blemished skin, and dandruff. 

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It is also very common in K-Beauty products, as it is part of a popular Korean natural preservative system trade named EURO-Napre (combined with Zanthoxylum Piperitum and Pulsatilla Koreana). 

Also-called: Argireline, Acetyl Hexapeptide-3 | What-it-does: cell-communicating ingredient, moisturizer/humectant

If you see a cosmetic product that claims that it has "Botox-like effect" then two things are almost certain: one, the product overpromises and two, it contains Argireline. 

So this one is the famous peptide that's marketed by its manufacturer as the "Botox in a jar". The basis for this claim is that it targets the same wrinkle forming mechanism (wrinkles caused by facial muscle movement) as Botox, but the way it works is very different. In addition, the extent to which it can prevent muscles from contracting (and to smooth wrinkles) is very different (otherwise why would anyone use still Botox?). 

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The manufacturer did several studies to prove that Argireline really works and it does (just not as well as Botox). In-vivo (made on real people) tests showed that using 10% Argireline solution around the eyes for 15 days decreased wrinkles depth by 17%. A Spanish University also did some research and found that Argireline increased the level of skin moisturization and decreased both the depth and width of wrinkles "significantly". 

This means, Acetyl Hexapeptide-8 does have some ability to smooth wrinkles (but not as well as Botox - sorry, if we sound like a broken record). Also, we have to agree with TruthInAging, that it's not a collagen builder and not a preventer of structural aging (think vitamin C, AHAs or retinol); it's just a quick fix. If you are looking for one, this could be your thing. If you are more of a "let's treat this aging thing properly" type, then it's probably not your thing.

Glycerin - goodie
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • Super common, used for more than 50 years
  • Not only a simple moisturizer but plays an important role in keeping the stuff between our skin cells healthy
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

We don't have description for this ingredient yet.

Caffeine - goodie
What-it-does: antioxidant

Hello, our favorite molecule that helps us wake up in the morning and then keeps us going through the day. As a super well-known stimulant from coffee, tea and plenty of other soft drinks, Caffeine needs no introduction. So we will skip right to the part where we talk about what the hell it does in so-so many cosmetic products.

Looking at the research, we were surprised to find how versatile Caffeine is. It is a small, water-loving molecule with pretty good skin penetration abilties. Once in the skin, it has nice antioxidant properties, meaning that it reduces the formation of evil free radicals and it might even be useful in preventing UV-induced skin cancers. 

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A well-known thing about Caffeine is that it improves the microcirculation of the blood vessels. Though conventional wisdom and anecdotal evidence says that this property is helpful for dark under-eye circles and puffy eyes, we have to mention that the double-blind research we have found about a 3% caffeine gel concluded that "the overall efficacy of the selected caffeine gel in reducing puffy eyes was not significantly different from that of its gel base."  But you know, the proof is in the pudding.

Another thing Caffeine is used for in body care products is its anti-cellulite effects. In theory, it can speed up the lipolysis process (the "fat burning"  by our cells) and stimulate the draining lymph system that might lead to the improvement of cellulite. But here again, the evidence that it actually makes a measurable, let alone visible,  improvement on actual human beings is limited (we could find only some animal skin studies or caffeine being combined with other actives). 

Last, but not least, we have to write about caffeine and hair growth. The theory is that it can inhibit the activity of the 5-α-reductase enzyme that plays an important role in hair loss and allows a renewed growth phase of the hair. We have found some recent and promising research to back this up. A 2017 study compared a 0.2% caffeine liquid with a 5% Minoxidil  (an FDA approved active to treat baldness) solution and found that  "a caffeine-based topical liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic alopecia", or English translation means that the caffeine liquid was pretty much as good as the FDA-approved Minoxidil stuff. Not bad!

Overall, we think that caffeine is a very versatile and biologically active ingredient. Even though some of its effects are more hyped up than backed up, it is still a nice to have on many ingredient lists. 

We don't have description for this ingredient yet.

What-it-does: antioxidant

We don't have description for this ingredient yet.

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

Expand to read more

In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Adenosine - goodie

Adenosine is an important little compound in our body that has a vital cell-signalling role. Research on smearing it on our face is also promising and shows so far a couple of things:

  • It can help with wound healing
  • It’s a good anti-inflammatory agent
  • It might even help with skin’s own collagen production and improve skin firmness and elasticity
  • It helps with barrier repair and protection
  • It might be even useful for the hair helping with hair thickness and hair growth
What-it-does: moisturizer/humectant

A corn sugar derived, water-soluble, pale yellow syrup, that nicely moisturizes the skin. It has a light and smooth skin feel, it is non-tacky, and it can improve the after-feel of the formula. It is also mild and gentle, popular in sensitive skin formulas.

Also-called: EGCG | What-it-does: antioxidant, soothing

If EGCG does not tell you anything, green tea sure does. We have written about green tea in excruciating details, so if you wanna become an expert in the "green tea in skincare" topic,  click here and read it

So now you know that EGCG is the magic ingredient in green tea. It's the most active polyphenol that green tea owes most of its magic properties to. It's a fantastic antioxidant, anti-inflammatory and anticarcinogenic agent. Be happy, if you spot it on the ingredient list. 

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