Follow us on our new Insta page »
dr. denese Skinscience Essential Radiance Enzyme-Rich Cleansing Cream

Skinscience Essential Radiance Enzyme-Rich Cleansing Cream

This luxurious 3-in-1 cleanser is the ultimate first step in prepping the skin. A moisturizing cream cleanser that removes dirt, oil and surface debris without stripping or over-drying.
Uploaded by: mellybelly on

Skim through

Ingredient name what-it-does irr., com. ID-Rating
Glycerin skin-identical ingredient, moisturizer/​humectant 0, 0 superstar
Carthamus Tinctorius (Safflower) Seed Oil antioxidant, emollient 0, 0-2 goodie
Helianthus Annuus (Sunflower) Seed Oil emollient 0, 0 goodie
Glycolic Acid exfoliant, buffering superstar
Amaranthus Caudatus Seed Extract emollient goodie
Carica Papaya (Papaya) Fruit Extract
Rosmarinus Officinalis (Rosemary) Leaf Extract antioxidant, soothing, antimicrobial/​antibacterial goodie
Sodium PCA skin-identical ingredient, moisturizer/​humectant 0, 0 goodie
Sodium Lactate buffering, moisturizer/​humectant goodie
Arginine skin-identical ingredient goodie
Aspartic Acid skin-identical ingredient goodie
Pca skin-identical ingredient, moisturizer/​humectant goodie
Glycine skin-identical ingredient goodie
Alanine skin-identical ingredient goodie
Serine skin-identical ingredient goodie
Valine skin-identical ingredient goodie
Proline skin-identical ingredient goodie
Threonine skin-identical ingredient goodie
Isoleucine skin-identical ingredient goodie
Histidine skin-identical ingredient, moisturizer/​humectant goodie
Phenylalanine skin-identical ingredient goodie
Diisostearyl Malate emollient, surfactant/​cleansing
Hydroxypropyl Methylcellulose surfactant/​cleansing, viscosity controlling 0, 1
PEG-40 Hydrogenated Castor Oil emulsifying, surfactant/​cleansing
Acrylates/C10-30 Alkyl Acrylate Crosspolymer viscosity controlling
Benzophenone-4 sunscreen
Sodium Hydroxide buffering
Disodium EDTA chelating
Phenoxyethanol preservative
Ethylhexylglycerin preservative
Fragrance perfuming icky
Water solvent
Sodium Cocoyl Isethionate surfactant/​cleansing
Cetyl Alcohol emollient, viscosity controlling 2, 2
Stearic Acid emollient, viscosity controlling 0, 2-3
Cocamidopropyl Betaine surfactant/​cleansing

dr. denese Skinscience Essential Radiance Enzyme-Rich Cleansing Cream
Ingredients explained

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

Also-called: Safflower Seed Oil | What-it-does: antioxidant, emollient | Irritancy: 0 | Comedogenicity: 0-2

The oil coming from the seeds of the yellow flowered safflower plant. Similar to other plant oils, it's loaded with nourishing and moisturizing fatty acids: it's a high linoleic acid oil (70%) and has only smaller amounts of oleic acid (11%) (this might be great for acne-prone skin). It also contains antioxidant vitamin E (44mg/100g alpha-tocopherol).

Also-called: Sunflower Oil | What-it-does: emollient | Irritancy: 0 | Comedogenicity: 0

Sunflower does not need a big intro as you probably use it in the kitchen as cooking oil, or you munch on the seeds as a healthy snack or you adore its big, beautiful yellow flower during the summer - or you do all of these and probably even more. And by even more  we mean putting it all over your face as sunflower oil is one of the most commonly used plant oils in skincare.

It’s a real oldie: expressed directly from the seeds, the oil is used not for hundreds but thousands of years. According to The National Sunflower Association, there is evidence that both the plant and its oil were used by American Indians in the area of Arizona and New Mexico about 3000 BC. Do the math: it's more than 5000 years – definitely an oldie.

Glycolic Acid - superstar
What-it-does: exfoliant, buffering
  • It’s the most researched AHA with the most proven skin benefits
  • It gently lifts off dead skin cells to reveal newer, fresher, smoother skin
  • It can help skin’s own collagen production that results in firmer, younger skin
  • It can fade brown spots caused by sun damage or PIH
  • Choose a product where you know the concentration and pH value because these two greatly influence effectiveness
  • Don’t forget to use your sunscreen (in any case but especially so next to an AHA product)
  • Slight stinging or burning with a stronger AHA product is normal
  • If your skin is very sensitive, rosacea prone choose rather a BHA or PHA product
Read all the geeky details about Glycolic Acid here >>

Also-called: Amaranth Seed Extract | What-it-does: emollient

It's the seed extract of a plant called amaranth or love-lies-bleeding.  It's a really ancient plant grown by Aztecs, Incas and Mayas as their main food and they called it “the golden grain”. They believed it had supernatural powers. Nowadays it's a popular health food because the seeds have great nutritional benefits and are high in protein.

As for skincare there are two types of the seed extract: 

Also-called: Papaya Fruit Extract

We don't have description for this ingredient yet.

Also-called: Rosemary Leaf Extract | What-it-does: antioxidant, soothing, antimicrobial/antibacterial

The extract coming from the lovely herb, rosemary. It contains lots of chemicals, including flavonoids, phenolic acids, and diterpenes. Its main active is rosmarinic acid, a potent antioxidant, and anti-inflammatory. It has also anti-bacterial, astringent and toning properties. 

The leaves contain a small amount of essential oil (1-2%) with fragrant components, so if you are allergic to fragrance, it might be better to avoid it. 

Sodium PCA - goodie
Also-called: Sodium Pyrrolidone Carboxylic Acid | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

PCA stands for Pyrrolidone Carboxylic Acid and though it might not sound like it, it is a thing that can be found naturally in our skin. The sodium salt form of PCA is an important skin-identical ingredient and great natural moisturizer that helps the skin to hold onto water and stay nicely hydrated. 

The sodium salt of lactic acid. It's a great skin moisturizer and also used to regulate the pH value of the cosmetic formula. It's a natural ingredient approved by both ECOCERT and COSMOS.

Arginine - goodie

A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing

Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former.  Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs

Aspartic Acid - goodie

A non-essential amino acid  (important building block of collagen and elastin) that hydrates the skin. It is also used to set the pH of the cosmetic product (buffering).

Pca - goodie
Also-called: Pyrrolidone Carboxylic Acid | What-it-does: skin-identical ingredient, moisturizer/humectant

PCA stands for Pyrrolidone Carboxylic Acid and though it might not sound like it, it is a thing that can be found naturally in our skin. In fact, after amino acids, it is the second biggest NMF component of the skin with 12% being PCA of the NMF composition of normal skin.  So similar to other NMFs, it's a skin goodie that helps the skin to hold onto water and stay nicely hydrated. 

Glycine - goodie

A non-essential amino acid (the building blocks of skin proteins, like collagen or elastin), that the body can produce itself, but its production decreases with age. When you put it all over your face, it works as a moisturizer and maybe more. 

According to great skincare blog Futurederm, glycine might help with wound healing and tissue repair and when used together with other amino acids, leucine and proline it might improve wrinkles

Alanine - goodie

A non-essential amino acid (a building block of skin proteins like collagen or elastin) that hydrates the skin.

Serine - goodie

Serine is an amino acid that most often comes to the formula as part of a moisturizing complex. It's a non-essential amino acid (meaning that our body can synthesize it) and serves as a water-binding ingredient.

In general, amino acids are great skincare ingredients that play an important role in proper skin hydration but there is not much info out there about what specifically serine can do for the skin.

Valine - goodie

An essential amino acid (a building block of skin proteins like collagen) that our body cannot produce itself but has to take from external sources, like diet. 

It's a branched chain amino acid that is claimed to enhance energy, increase endurance and aid in muscle tissue recovery and repair when taken as a supplement. It's not clear what valine does when you put it on the skin, but as all amino acids, it must be at least a great skin hydrator.

Proline - goodie

A non-essential amino acid (meaning that our body can produce it) that's also one of the major building blocks of collagen. According to the Futurederm blog, it might be able to improve wrinkles when combined with other amino acids, glycine and leucine

Threonine - goodie

An essential amino acid that's also a key building block of collagen and elastin. When taken orally, it helps the digestive and intestinal tracts function more smoothly and also helps the absorption of nutrients. As for skincare, it is not clear what it does other than being a skin hydrator

Isoleucine - goodie

A branch-chained, essential amino acid that can be found in things like almond, cashew or soy protein. When taken orally it may promote protein synthesis. As for skincare - like all the amino acids - it's a skin-identical ingredient and moisturizer. It also seems to be useful as a barrier repair ingredient.  

Histidine - goodie

A semi-essential amino acid meaning that enough has to be eaten from it so that the body does not use up essential amino acids (that our body cannot produce itself) to synthesize it. It has an important role in regulating the immune defense, allergic reactions, and inflammatory processes in the body.

As for skincare, it's a skin moisturizer that might also protect from some skin infections

Phenylalanine - goodie

An essential amino acid that the body cannot produce itself but has to take from the diet. Combined with UVA exposure, phenylalanine is used in the treatment of vitiligo (a pigmentation disorder where patches of the skin lose the pigment).

We don't have description for this ingredient yet.

What-it-does: surfactant/cleansing, viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A handy helper ingredient (a polymer, i.e. big molecule from repeated subunits) that is used to stabilize emulsions as well as to thicken up products. It can also stabilize foam in cleansing products. 

A mildly viscous, amber-colored liquid with fatty odor, made from Castor Oil and polyethylene glycol (PEG).

If it were a person, we’d say, it’s agile, diligent & multifunctional. It’s mostly used as an emulsifier and surfactant but most often it is used to solubilize fragrances into water-based formulas.

Though its long name does not reveal it, this polymer molecule (big molecule from repeated subunits or monomers) is a relative to the super common, water-loving thickener, Carbomer. Both of them are big molecules that contain acrylic acid units, but Acrylates/C10-30 Alkyl Acrylate Crosspolymer also contains some other monomers that are hydrophobic, i.e. water-hating. 

This means that our molecule is part water- and part oil-loving, so it not only works as a thickener but also as an emulsion stabilizer. It is very common in gel-type formulas that also contain an oil-phase as well as in cleansers as it also works with most cleansing agents (unlike a lot of other thickeners). 

Also-called: Sulisobenzone | What-it-does: sunscreen

A water-soluble, chemical sunscreen agent that is a secondary UVB absorber with some activity in the short UVA range as well. Being a secondary UV absorber means that its protection is weak and it has to be combined with other sunscreen filters for proper sun protection. 

More often than not, Benzophenone-4 is not used as a sunscreen agent but as a photoprotectant to extend product shelf life, or as a color-protectant for products in clear packages. 

Also-called: lye | What-it-does: buffering

The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right. 

For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.  

What-it-does: chelating

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

It is typically used in tiny amounts, around 0.1% or less.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

What-it-does: preservative, deodorant

If you have spotted ethylhexylglycerin on the ingredient list, most probably you will see there also the current IT-preservative, phenoxyethanol. They are good friends because ethylhexylglycerin can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too.

Also, it's an effective deodorant and a medium spreading emollient

Fragrance - icky
Also-called: Fragrance, Parfum;Parfum/Fragrance | What-it-does: perfuming

Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!). 

If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.  

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

What-it-does: surfactant/cleansing

A cleansing agent that's claimed to be so gentle on the skin that it hardly impacts the skin barrier. It also gives a rich, creamy foam, it's based on vegetable fatty acids and is readily biodegradable.

It's an especially important and popular ingredient in "syndet bars" (or soapless soaps). Dr. Leslie Baumann says in her great Cosmetic Dermatology book that thanks to the unique molecular characteristic of Sodium Cocoyl Isethionate, it "has defined a new dimension in the mildness of cleansing bars".

What-it-does: emollient, viscosity controlling, emulsion stabilising | Irritancy: 2 | Comedogenicity: 2

A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.

What-it-does: emollient, viscosity controlling | Irritancy: 0 | Comedogenicity: 2-3

A common multi-tasker fatty acid. It makes your skin feel nice and smooth (emollient), gives body to cream type products and helps to stabilize water and oil mixes (aka emulsions).

What-it-does: surfactant/cleansing

Super common ingredient in all kinds of cleansing products: face and body washes, shampoos and foam baths. 

Number one reason for its popularity has to do with bubbles. Everyone loves bubbles. And cocamidopropyl betaine is great at stabilizing them. 

You may also want to take a look at...

what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does antioxidant | emollient
irritancy, com. 0, 0-2
Safflower Seed Oil - emollient plant oil with moisturizing fatty acids (linoleic: 70%, oleic: 11%) and antioxidant vitamin E (44mg/100g alpha-tocopherol). [more]
what‑it‑does emollient
irritancy, com. 0, 0
Sunflower Oil - it's a great emollient that protects & enhances the skin barrier. [more]
what‑it‑does exfoliant | buffering
The most researched and well-known AHA exfoliant. It gently lifts off dead skin cells to reveal newer, fresher, smoother skin. In larger concentration (>10%) it's a proven collagen booster. [more]
what‑it‑does emollient
It's the seed extract of the popular health food, amaranth. The oily extract works as a great emollient, moisturizing plant oil for skin and hair. [more]
what‑it‑does antioxidant | soothing | antimicrobial/antibacterial
Rosemary leaf extract - Its main active is rosmarinic acid, a potent antioxidant, and anti-inflammatory. It has also anti-bacterial, astringent and toning properties. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
It's an important skin-identical ingredient and great natural moisturizer that helps the skin to hold onto water and stay nicely hydrated. [more]
what‑it‑does buffering | moisturizer/humectant
The sodium salt of lactic acid. It's a great skin moisturizer and also used to regulate the pH value of the cosmetic formula. [more]
what‑it‑does skin-identical ingredient
An amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor and might also help to speed up wound healing.  [more]
what‑it‑does skin-identical ingredient
A non-essential amino acid  (important building block of collagen and elastin) that hydrates the skin. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
PCA stands for Pyrrolidone Carboxylic Acid and though it might not sound like it, it is a thing that can be found naturally in our skin. In fact, after amino acids, it is the second biggest NMF component of the skin with 12% being PCA of the NMF composition of normal skin.  So similar to other NMFs, it's a skin goodie that  [more]
what‑it‑does skin-identical ingredient
An amino acid (the building blocks of skin proteins, like collagen) that hydrates the skin and might help wound healing and improve wrinkles. [more]
what‑it‑does skin-identical ingredient
A non-essential amino acid (a building block of skin proteins like collagen or elastin) that hydrates the skin.
what‑it‑does skin-identical ingredient
Serine is an amino acid that most often comes to the formula as part of a moisturizing complex. It's a non-essential amino acid (meaning that our body can synthesize it) and serves as a water-binding ingredient.In general, amino acids are great skincare ingredients that play an important role in proper skin hydration but there is not much info out there about what specifically serine can d [more]
what‑it‑does skin-identical ingredient
An essential amino acid (a building block of skin proteins like collagen) that is a skin hydrator. [more]
what‑it‑does skin-identical ingredient
A non-essential amino acid (meaning that our body can produce it) that might be able to improve wrinkles combined with other amino acids, glycine and leucine. [more]
what‑it‑does skin-identical ingredient
An essential amino acid (important building block of collagen and elastin) that hydrates the skin. [more]
what‑it‑does skin-identical ingredient
An essential amino acid that hydrates the skin and might be also a barrier repair ingredient. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
An amino acid that is important in regulating the immune defense and inflammatory processes in the body. It's a skin moisturizer that might protect from skin infections. [more]
what‑it‑does skin-identical ingredient
An essential amino acid that is used in the treatment of vitiligo. [more]
what‑it‑does emollient | surfactant/cleansing
what‑it‑does surfactant/cleansing | viscosity controlling
irritancy, com. 0, 1
A handy helper ingredient (a polymer, i.e. big molecule from repeated subunits) that is used to stabilize emulsions as well as to thicken up products. It can also stabilize foam in cleansing products.  [more]
what‑it‑does emulsifying | surfactant/cleansing
A mildly viscous, amber-colored liquid that works as an emulsifier and surfactant. [more]
what‑it‑does viscosity controlling
A common helper ingredient that stabilizes emulsions and helps to thicken up products. [more]
what‑it‑does sunscreen
A water-soluble, chemical sunscreen agent that is a secondary UVB absorber with some activity in the short UVA range as well. Being a secondary UV absorber means that its protection is weak and it has to be combined with other sunscreen filters for proper sun protection. More often than not, Benzophenone-4 is not used as a sunscreen agent but as a photoprotectant to extend product&nb [more]
what‑it‑does buffering
Lye - A solid white stuff that’s very alkaline and used in small amount to adjust the pH of the product.  [more]
what‑it‑does chelating
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does preservative
It can boost the effectiveness of phenoxyethanol (and other preservatives) and as an added bonus it feels nice on the skin too. [more]
what‑it‑does perfuming
The generic term for nice smelling stuff put into cosmetic products so that the end product also smells nice. It is made up of 30 to 50 chemicals on average. [more]
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does surfactant/cleansing
A cleansing agent that's claimed to be so gentle on the skin that it hardly impacts the skin barrier. It also gives a rich, creamy foam, it's based on vegetable fatty acids and is readily biodegradable. [more]
what‑it‑does emollient | viscosity controlling
irritancy, com. 2, 2
A fatty (the good, non-drying kind of) alcohol that makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier).
what‑it‑does emollient | viscosity controlling
irritancy, com. 0, 2-3
A common multi-tasker fatty acid that works as an emollient, thickener and emulsion stabilizer. [more]
what‑it‑does surfactant/cleansing
Super common ingredient in all kinds of cleansing products: face and body washes, shampoos and foam baths. Number one reason for its popularity has to do with bubbles. [more]