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Dermedic Hydrain 2

Hydrain 2

The intensively moisturizing cream with prolonged action from the Hydrain2 series is designed for the care of dehydrated, dry, thin, tense, sensitive skin, prone to redness and burning, not tolerating traditional cosmetics. It can be used when treating rosacea and juvenile acne.
Uploaded by: emarily on

Dermedic Hydrain 2
Ingredients explained

Also-called: Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Also-called: Mineral Oil | What-it-does: emollient, solvent | Irritancy: 0 | Comedogenicity: 0-2

The famous or maybe rather infamous mineral oil. The clear oily liquid that is the "cheap by-product" of refining crude oil and the one that gets a lot of heat for its poor provenance. It is a very controversial ingredient with pros and cons and plenty of myths around it. So let us see them:  

The pros of mineral oil
Trust us, if something is used for more than 100 years in cosmetic products, it has advantages. Chemically speaking, cosmetic grade mineral oil is a complex mixture of highly refined saturated hydrocarbons with C15-50 chain length. It is not merely a "by-product" but rather a specifically isolated part of petroleum that is very pure and inert.

It is a great emollient and moisturizer working mainly by occlusivity. Occlusivity is one of the basic mechanisms of how moisturizers work and it means that mineral oil sits on top of the skin and hinders so-called trans-epidermal water loss, i.e water evaporating out of your skin. When compared to heavy-duty plant oil, extra virgin coconut oil, the two of them were equally efficient and safe as moisturizers in treating xerosis, a skin condition connected to very dry skin.

The other thing that mineral oil is really good at is being non-irritating to the skin. The chemical composition of plant oils is more complex with many more possible allergens or irritating components, while mineral oil is simple, pure and sensitivity to it is extremely rare. If you check out the classic French pharmacy brands and their moisturizers for the most sensitive, allergy prone skin, they usually contain mineral oil. This is no coincidence. 

The cons of mineral oil
The pros of mineral oil can be interpreted as cons if we look at them from another perspective. Not penetrating the skin but mostly just sitting on top of it and not containing biologically active components, like nice fatty acids and vitamins mean that mineral oil does not "nourish" the skin in the way plant oils do. Mineral oil does not give the skin any extra goodness, it is simply a non-irritating moisturizer working mainly by occlusivity. 

The myths around mineral oil
Badmouthing mineral oil is a favorite sport of many, it is a cheap material and being connected to petrolatum makes it fairly easy to demonize. 

While it is true that industrial grade mineral oil contains carcinogenic components (so-called polycyclic compounds), these are completely removed from cosmetic and food grade mineral oil and there is no scientific data showing that the pure, cosmetic grade version is carcinogenic.

What is more, in terms of the general health effects of mineral oils used in cosmetics, a 2017 study reviewed the data on their skin penetration and concluded that "the cosmetic use of mineral oils and waxes does not present a risk to consumers due to a lack of systemic exposure."  

Another super common myth surrounding mineral oil is that it is comedogenic. A 2005 study titled "Is mineral oil comedogenic?" examined this very question and guess what happened? The study concluded that  "based on the animal and human data reported, along with the AAD recommendation, it would appear reasonable to conclude that mineral oil is noncomedogenic in humans.

Overall, we feel that the scaremongering around mineral oil is not justified. For dry and super-sensitive skin types it is a great option. However, if you do not like its origin or its heavy feeling or anything else about it, avoiding it has never been easier. Mineral oil has such a bad reputation nowadays that cosmetic companies hardly dare to use it anymore. 

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: solvent

It's a type of glycol that - according to the manufacturer - is an extremely good replacement for other glycols like propylene or butylene glycol. Its main job is to be a solvent, but it has also very good antimicrobial properties and acts as a true preservative booster. Also helps with skin hydration without stickiness or tacky feel.

Also-called: Shea Butter | What-it-does: emollient, viscosity controlling

Unless you live under a rock you must have heard about shea butter. It's probably the most hyped up natural butter in skincare today. It comes from the seeds of African Shea or Karite Trees and used as a magic moisturizer and emollient.

But it's not only a simple emollient, it regenerates and soothes the skin, protects it from external factors (such as UV rays or wind) and is also rich in antioxidants (among others vitamin A, E, F, quercetin and epigallocatechin gallate). If you are looking for rich emollient benefits + more, shea is hard to beat. 

What-it-does: emollient, solvent

A super commonly used 5 unit long, cyclic structured silicone that is water-thin and does not stay on the skin but evaporates from it (called volatile silicone). Similar to other silicones, it gives skin and hair a silky, smooth feel

It's often combined with the non-volatile (i.e. stays on the skin) dimethicone as the two together form a water-resistant, breathable protective barrier on the skin without a negative tacky feel.

A thick, high molecular weight silicone that is usually diluted in another, lighter silicone fluid (like dimethicone or cyclopentasiloxane). The dimethiconol containing silicone blends leave a silky smooth, non-greasy film on the skin.

Urea - goodie
Also-called: Carbamide | What-it-does: skin-identical ingredient, moisturizer/humectant

Yes, it's the thing that can be found naturally in pee. And in the skin. It is an awesome natural moisturizing factor, aka NMF.  NMFs are important components that help the skin to hold onto water and keep it plump, elastic and hydrated. Urea makes up about 7% of NMFs next to other things such as amino acids (40%), PCA (12%) or Lactate (12%).

What makes urea special, is that it is not only a simple moisturizer, but it is thought to be a "small-molecule regulator of epidermal structure and function" meaning that it has a bunch of extra biological activities. It acts as a mild keratolytic agent (some of its moisturizing action is thought to come from urea's ability to break down bonds in the protein called filaggrin and thus freeing up amino acids in the skin), enhances antimicrobial peptide expression and improves skin barrier function

Being a mild keratolytic agent and strong moisturizer means that high-percentage (10-40%) urea treatments are found effective in a bunch of skin disorders connected to excessive dryness and malfunctioning skin barrier such as ichthyosis, xerosis, psoriasis, eczema and seborrheic dermatitis.  

Overall, just like glycerin, urea is a real oldie but a goodie, a nice ingredient in any moisturizer.

What-it-does: surfactant/cleansing, emulsifying | Irritancy: 0 | Comedogenicity: 0

A very common water-loving surfactant and emulsifier that helps to keep water and oil mixed nicely together. 

It's often paired with glyceryl stearate - the two together form a super effective emulsifier duo that's salt and acid tolerant and works over a wide pH range. It also gives a "pleasing product aesthetics", so no wonder it's popular.

What-it-does: emollient, emulsifying | Irritancy: 0 | Comedogenicity: 1-2

A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.

Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.

It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".

What-it-does: emollient, emulsifying, viscosity controlling, surfactant/cleansing, emulsion stabilising | Irritancy: 2 | Comedogenicity: 2

A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.

What-it-does: emollient, viscosity controlling | Irritancy: 0 | Comedogenicity: 2-3

A common multi-tasker fatty acid. It makes your skin feel nice and smooth (emollient), gives body to cream type products and helps to stabilize water and oil mixes (aka emulsions).

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

What-it-does: buffering | Irritancy: 0 | Comedogenicity: 2

It’s a little helper ingredient that helps to set the pH of a cosmetic formulation to be just right. It’s very alkaline (you know the opposite of being very acidic): a 1% solution has a pH of around 10.

It does not have the very best safety reputation but in general, you do not have to worry about it. 

What is true is that if a product contains so-called N-nitrogenating agents (e.g.: preservatives like 2-Bromo-2-Nitropropane-1,3-Diol, 5-Bromo-5-Nitro- 1,3-Dioxane or sodium nitrate - so look out for things with nitro, nitra in the name) that together with TEA can form some not nice carcinogenic stuff (that is called nitrosamines). But with proper formulation that does not happen, TEA in itself is not a bad guy. 

But let’s assume a bad combination of ingredients were used and the nitrosamines formed. :( Even in that case you are probably fine because as far as we know it cannot penetrate the skin. 

But to be on the safe side, if you see Triethanolamine in an INCI and also something with nitra, nitro in the name of it just skip the product, that cannot hurt.

Though its long name does not reveal it, this polymer molecule (big molecule from repeated subunits or monomers) is a relative to the super common, water-loving thickener, Carbomer. Both of them are big molecules that contain acrylic acid units, but Acrylates/C10-30 Alkyl Acrylate Crosspolymer also contains some other monomers that are hydrophobic, i.e. water-hating. 

This means that our molecule is part water- and part oil-loving, so it not only works as a thickener but also as an emulsion stabilizer. It is very common in gel-type formulas that also contain an oil-phase as well as in cleansers as it also works with most cleansing agents (unlike a lot of other thickeners). 

It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range. 

Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415). 

What-it-does: preservative

A controversial preservative that has formaldehyde-releasing properties. It works great against bacteria and also has mild fungicide abilities. 

Cosmetic chemist, Colin wrote a great article about formaldehyde and DMDM Hydantoin.  He writes that formaldehyde is the perfect example of "the dose makes the poison" principle. It's a natural stuff that can also be found in fresh fruits and vegetables, and eating it in tiny amounts is totally ok. However, in larger amounts (according to Wikipedia 30 mL of a solution containing 37% formaldehyde) it's deadly. 

The amount of formaldehyde used in cosmetics either neat or through formaldehyde-releasing preservatives is tiny. Probably that is why the Cosmetic Ingredient Review Broad concluded both in 1988 and in 2008 that DMDM Hydantoin is "safe as used in cosmetics".

However, Colins argues that in the case of formaldehyde-releasing preservatives, formaldehyde is released slowly and the skin has probably not evolved to deal with that. The lingering formaldehyde might be toxic to the Langerhans Cells that are important for the skin's defense system. Another potential issue is that formaldehyde-releasers might also release other things while reacting with amino acids in the skin that is probably the explanation why some people are not allergic to formaldehyde but are allergic to formaldehyde-releasing preservatives. These are all theories, far from proven facts, but we feel that there are some justified reasons why formaldehyde-releasing preservatives and Dmdm Hydantoin count as controversial. 

All in all, it's up to you to decide if you wanna avoid this preservative group or not. If so, there are other, less risky and more skin-friendly options out there.

What-it-does: preservative

This totally unpronounceable ingredient (let’s take a shortcut: MCI) is a super effective preservative with both antibacterial and antifungal effects that works at very low concentrations. 

The bad news with it though is that it can sensitize the skin easily (it’s a so-called non-fragrance allergen). It’s not permitted to be used alone, but only with its BFF, methylisothiazolinone (MI), another icky preservative. Together they have a broad spectrum antimicrobial effect but are permitted to be used only in rinse-off products (under 0.0015%).

What-it-does: preservative

As you may guess, if something is only recommended in products that you rinse off (cleansers and shampoos), then it’s probably not the best ingredient for the skin.

Methylisothiazolinone (MI) is a preservative that' super efficient against bacteria at surprisingly low concentrations. The problem with it though is that it can also sensitize and irritate the skin quite easily when it comes in leave-on formulas.

Currently, some countries are considering to ban it entirely (like Denmark) and the permitted use level is very low (under 0.01%). Luckily there are plenty of products on the market with other preservative options so if you are a better safe than sorry type it's probably best to avoid it. 

What-it-does: chelating

An abbreviation that pops up on a lot of ingredient lists. It stands for EthyleneDiamineTetraacetic Acid and it's a famous molecule for being an excellent chelating agent, i.e. a molecule that can bind to metal ions (coming usually from water) and make them harmless in a cosmetic formula. With a chelating agent, cosmetic formulas stay nice longer.

EDTA is an acid molecule and its salt versions are even more often used, such as the super common Disodium EDTA

Parfum - icky
Also-called: Fragrance, Parfum;Parfum/Fragrance | What-it-does: perfuming

Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!). 

If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.  

Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!). 

You may also want to take a look at...

what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does emollient | solvent
irritancy, com. 0, 0-2
A clear, oily liquid that comes from refining crude oil. Even though it is a highly controversial ingredient, the scientific consensus is that it is a safe, non-irritating and effective emollient and moisturizer working mainly by occlusivity. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does solvent
A type of glycol. Its main job is to be a solvent, but it has also very good antimicrobial properties and acts as a true preservative booster. [more]
what‑it‑does emollient | viscosity controlling
Shea butter that's considered to be a magic moisturizer and emollient. It is also soothing and rich in antioxidants. [more]
what‑it‑does emollient | solvent
It's a super commonly used water-thin volatile silicone that gives skin and hair a silky, smooth feel.  [more]
what‑it‑does emollient | moisturizer/humectant
A thick, high molecular weight silicone that is usually diluted in a lighter silicone fluid. The dimethiconol containing silicone blends leave a silky smooth, non-greasy film on the skin. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
The thing in the pee that is also a natural moisturizing factor (NMF) with mild keratolytic and strong skin moisturizing superpowers. [more]
what‑it‑does surfactant/cleansing | emulsifying
irritancy, com. 0, 0
A commonly used water-soluble surfactant and emulsifier. [more]
what‑it‑does emollient | emulsifying
irritancy, com. 0, 1-2
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
what‑it‑does emollient | emulsifying | viscosity controlling | surfactant/cleansing
irritancy, com. 2, 2
A fatty (the good, non-drying kind of) alcohol that makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier).
what‑it‑does emollient | viscosity controlling
irritancy, com. 0, 2-3
A common multi-tasker fatty acid that works as an emollient, thickener and emulsion stabilizer. [more]
what‑it‑does antioxidant
irritancy, com. 0, 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
what‑it‑does buffering
irritancy, com. 0, 2
Helps to set the pH of a cosmetic formulation to be right. It’s very alkaline. [more]
what‑it‑does viscosity controlling
A common helper ingredient that stabilizes emulsions and helps to thicken up products. [more]
what‑it‑does viscosity controlling
A super commonly used thickener and emulsion stabilizer. [more]
what‑it‑does preservative
A controversial preservative that has formaldehyde-releasing properties. It works great against bacteria and also has mild fungicide abilities.  [more]
what‑it‑does preservative
Preservative with relatively high irritation risk. It's always used together with Methylisothiazolinone. [more]
what‑it‑does preservative
Preservative with relatively high irritation risk that is used mainly in rinse-off products. [more]
what‑it‑does chelating
An abbreviation that pops up on a lot of ingredient lists. It stands for EthyleneDiamineTetraacetic Acid and it's a famous molecule for being an excellent chelating agent, i.e. a molecule that can bind to metal ions (coming usually from water) and make them harmless in a cosmetic formula. [more]
what‑it‑does perfuming
The generic term for nice smelling stuff put into cosmetic products so that the end product also smells nice. It is made up of 30 to 50 chemicals on average. [more]