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Dermasence Chrono Retare Anti-Aging-Serum

Chrono Retare Anti-Aging-Serum

The anti-aging serum is an innovative care concentrate for the regeneration of mature skin from 45 years. With ectoin and olive leaf extract, it has a cell-protecting effect and reduces [more] [more] premature skin ageing processes. High-dose hyaluronic acid provides intense moisture, making the skin appear firmer and smoother. The particularly rich texture protects the natural barrier of the skin, has a soothing and regenerating effect. The serum supports the natural radiance of the skin and can supplement the care as a daily serum. [less]
Uploaded by: samuelmatn on 28/07/2019

Dermasence Chrono Retare Anti-Aging-Serum
Ingredients explained

Also-called: Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

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Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Glycerin - superstar
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits at higher concentrations up to 20-40% (around 10% is a good usability-effectiveness sweet spot)
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

Ectoin - goodie
Also-called: 28Extremoin

We don't have description for this ingredient yet.

Panthenol - goodie
Also-called: Pro-Vitamin B5 | What-it-does: soothing, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid). 

Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. 

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Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.

Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. 

If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.

As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily. 

A handy helper ingredient that comes in a white powder form and works as an anti-caking and oil-absorbing agent. It also gives products good spreadability, long lasting and velvet touch characteristics. It is popular both in skincare and makeup products.

What-it-does: emollient

A clear, colorless, almost odorless oil that spreads nicely and easily and gives a velvet dry skin feel. It is good friends with sunscreen agents and helps to solubilize them. Also, it makes sunscreens feel lighter and spread easier. 

What-it-does: emollient

A helpful emollient ingredient that gives products a light, smooth-skin feeling. You’ll find it mostly in products containing SPF, as, according to several manufacturers, it can increase the water resistance and spreadability of UV filters. With better spreadability, less filters are needed to provide the same SPF, making the formula lighter and nicer to use and with improved water resistance, your protection will last that bit longer in the pool.

What-it-does: emollient, emulsifying

A glycerin and stearic acid based ingredient that helps oil and water to mix nicely together, aka emulsifier.  It is PEG-free and based on renewable raw materials.

It usually comes to the formula with its emulsifier buddy,  Polyglyceryl-6 Behenate, and the duo is especially recommended for formulating low-viscous serums, lotions, and sprays.  As an added bonus, the duo is also described as providing "outstanding moisturization properties".

What-it-does: emulsion stabilising

A glycerin and behenic acid based ingredient that stabilizes oil-water mixes, aka emulsions. It usually comes to the formula with Polyglyceryl-6 Stearate, and the duo is helpful for making light serums and lotions. As an added bonus, they also work as a nice emollient and moisturizer

What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0

It’s the - sodium form - cousin of the famous NMFhyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here.  The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.

As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit  "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". 

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In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).

What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists. 

If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).

Also-called: Olive Leaf;Olea Europaea Leaf Extract

We don't have description for this ingredient yet.

Also-called: Vitamin E Acetate | What-it-does: antioxidant | Irritancy: 0 | Comedogenicity: 0

It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version. 

According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E. 

What-it-does: emollient, solvent

A clear, colorless and odorless oily liquid that works as a fast-spreading emollient with a dry skin feel

Also-called: Shea Butter | What-it-does: emollient

Unless you live under a rock you must have heard about shea butter. It's probably the most hyped up natural butter in skincare today. It comes from the seeds of African Shea or Karite Trees and used as a magic moisturizer and emollient.

But it's not only a simple emollient, it regenerates and soothes the skin, protects it from external factors (such as UV rays or wind) and is also rich in antioxidants (among others vitamin A, E, F, quercetin and epigallocatechin gallate). If you are looking for rich emollient benefits + more, shea is hard to beat. 

What-it-does: emollient

A clear, almost colorless (or slightly yellowish) oily liquid (an ester to be precise) that's used as a medium spreading emollient. It gives skin a nice and smooth after-feel and it's very good at reducing oiliness or greasiness coming from other heavier oils in the formula.

Though its long name does not reveal it, this polymer molecule (big molecule from repeated subunits or monomers) is a relative to the super common, water-loving thickener, Carbomer. Both of them are big molecules that contain acrylic acid units, but Acrylates/C10-30 Alkyl Acrylate Crosspolymer also contains some other monomers that are hydrophobic, i.e. water-hating. 

This means that our molecule is part water- and part oil-loving, so it not only works as a thickener but also as an emulsion stabilizer. It is very common in gel-type formulas that also contain an oil-phase as well as in cleansers as it also works with most cleansing agents (unlike a lot of other thickeners). 

What-it-does: emollient, emulsifying | Irritancy: 0 | Comedogenicity: 1-2

A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.

Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.

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It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".

What-it-does: emollient, viscosity controlling | Irritancy: 1 | Comedogenicity: 2

An extremely common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams and lotions. It also helps to stabilize oil-water mixes (emulsions), though it does not function as an emulsifier in itself. Its typical use level in most cream type formulas is 2-3%.  

It’s a so-called fatty alcohol, a mix of cetyl and stearyl alcohol, other two emollient fatty alcohols.  Though chemically speaking, it is alcohol (as in, it has an -OH group in its molecule), its properties are totally different from the properties of low molecular weight or drying alcohols such as denat. alcohol. Fatty alcohols have a long oil-soluble (and thus emollient) tail part that makes them absolutely non-drying and non-irritating and are totally ok for the skin.

We don't have description for this ingredient yet.

Also-called: Aristoflex AVC | What-it-does: viscosity controlling

A kind of polymer (big molecule from repeated subunits) that helps to create beautiful gel-like textures. It's also a texturizer and thickener for oil-in-water emulsions. It gives products a good skin feel and does not make the formula tacky or sticky. 

It works over a wide pH range and is used between 0.5-1.2%.

Parfum - icky
Also-called: Fragrance, Parfum;Parfum/Fragrance | What-it-does: perfuming

Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!). 

If you are someone who likes to know what you put on your face than fragrance is not your best friend - no way to know what’s really in it.  

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Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!). 

What-it-does: buffering

An alkaline (high pH, aka basic) material that is used to set the pH of the cosmetic formula to the right value

What-it-does: preservative

We don't have description for this ingredient yet.

What-it-does: sunscreen

Titanium Dioxide is one of the two members of the elite sunscreen group called physical sunscreens (or inorganic sunscreens if you’re a science geek and want to be precise).

Traditionally, UV-filters are categorized as either chemical or physical. The big difference is supposed to be that chemical agents absorb UV-light while physical agents reflect it like a bunch of mini umbrellas on top of the skin. While this categorization is easy and logical it turns out it's not true. A recent, 2016 study shows that inorganic sunscreens work mostly by absorption, just like chemical filters, and only a little bit by reflection (they do reflect the light in the visible spectrum, but mostly absorb in the UV spectrum).

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Anyway, it doesn't matter if it reflects or absorbs, Titanium Dioxide is a pretty awesome sunscreen agent for two main reasons: it gives a nice broad spectrum coverage and it's highly stable. Its protection is very good between 290 - 350 nm (UVB and UVA II range), and less good at 350-400 nm (UVA I) range. Regular sized Titanium Dioxide also has a great safety profile, it's non-irritating and is pretty much free from any health concerns (like estrogenic effect worries with some chemical filters).

The disadvantage of Titanium Dioxide is that it's not cosmetically elegant, meaning it's a white, "unspreadable" mess. Sunscreens containing Titanium Dioxide are often hard to spread on the skin and they leave a disturbing whitish tint. The cosmetic industry is, of course, really trying to solve this problem and the best solution so far is using nanoparticles. The itsy-bitsy Nano-sized particles improve both spreadability and reduce the whitish tint a lot, but unfortunately, it also introduces new health concerns. 

The main concern with nanoparticles is that they are so tiny that they are absorbed into the skin more than we want them (ideally sunscreen should remain on the surface of the skin). Once absorbed they might form unwanted complexes with proteins and they might promote the formation of evil free radicals. But do not panic, these are concerns under investigation. A 2009 review article about the safety of nanoparticles summarizes this, "to date, in-vivo and in-vitro studies have not demonstrated percutaneous penetration of nanosized particles in titanium dioxide and zinc oxide sunscreens". The English translation is, so far it looks like sunscreens with nanoparticles do stay on the surface of the skin where they should be.  

All in all, Titanium Dioxide is a famous sunscreen agent and for good reason, it gives broad spectrum UV protection (best at UVB and UVA II), it's highly stable, and it has a good safety profile. It's definitely one of the best UV-filter agents we have today, especially in the US where new-generation Tinosorb filters are not (yet) approved. 

We don't have description for this ingredient yet.

What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 0
  • It's a helper ingredient that improves the freeze-thaw stability of products
  • It's also a solvent, humectant and to some extent a penetration enhancer
  • It has a bad reputation among natural cosmetics advocates but cosmetic scientists and toxicology experts do not agree (read more in the geeky details section)
Read all the geeky details about Propylene Glycol here >>

Citric Acid - goodie
What-it-does: exfoliant, buffering

Citric acid comes from citrus fruits and is an AHA. If these magic three letters don’t tell you anything, click here and read our detailed description on glycolic acid, the most famous AHA. 

So citric acid is an exfoliant, that can - just like other AHAs - gently lift off the dead skin cells of your skin and make it more smooth and fresh. 

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There is also some research showing that citric acid with regular use (think three months and 20% concentration) can help sun-damaged skin, increase skin thickness and some nice hydrating things called glycosaminoglycans in the skin. 

But according to a comparative study done in 1995, citric acid has less skin improving magic properties than glycolic or lactic acid. Probably that’s why citric acid is usually not used as an exfoliant but more as a helper ingredient in small amounts to adjust the pH of a formulation. 

What-it-does: preservative

We don't have description for this ingredient yet.

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what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does soothing | moisturizer/humectant
irritancy, com. 0, 0
Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. [more]
what‑it‑does viscosity controlling
A handy helper ingredient that comes in a white powder form and works as an anti-caking and oil-absorbing agent. It also gives products good spreadability, long lasting and velvet touch characteristics.
what‑it‑does emollient
A clear, colorless, almost odorless oil that spreads nicely and easily and gives a velvet dry skin feel. It is good friends with sunscreen agents and helps to solubilize them.
what‑it‑does emollient
A helpful emollient ingredient that gives products a light, smooth-skin feeling. You’ll find it mostly in products containing SPF, as, according to several manufacturers, it can increase the water resistance and spreadability of UV filters. [more]
what‑it‑does emollient | emulsifying
A glycerin and stearic acid based ingredient that helps oil and water to mix nicely together, aka emulsifier.  It is PEG-free and based on renewable raw materials.It usually comes to the formula with its emulsifier buddy,  Polyglyceryl-6 Behenate, and the duo is especially recommended for formulating low-viscous serums, lotions,  [more]
A glycerin and behenic acid based ingredient that stabilizes oil-water mixes, aka emulsions. It usually comes to the formula with Polyglyceryl-6 Stearate, and the duo is helpful for making light serums and lotions. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
It's the salt form of famous humectant and natural moisturizing factor, hyaluronic acid. It can bind huge amounts of water and it's pretty much the current IT-moisturizer. [more]
what‑it‑does antioxidant
irritancy, com. 0, 0
A form of vitamin E that works as an antioxidant. Compared to the pure form it's more stable, has longer shelf life, but it's also more poorly absorbed by the skin. [more]
what‑it‑does emollient | solvent
A clear, colorless and odorless oily liquid that works as a fast-spreading emollient with a dry skin feel. 
what‑it‑does emollient
Shea butter that's considered to be a magic moisturizer and emollient. It is also soothing and rich in antioxidants. [more]
what‑it‑does emollient
A clear, almost colorless oily liquid that's used as a medium spreading emollient. It gives skin a nice and smooth after-feel and it's very good at reducing oiliness or greasiness coming from other heavier oils in the formula.
what‑it‑does viscosity controlling
A common helper ingredient that stabilizes emulsions and helps to thicken up products. [more]
what‑it‑does emollient | emulsifying
irritancy, com. 0, 1-2
Waxy, white, solid stuff that helps water and oil to mix together and leaves the skin feeling soft and smooth. [more]
what‑it‑does emollient | viscosity controlling
irritancy, com. 1, 2
A super common multitasker ingredient that gives your skin a nice soft feel (emollient) and gives body to creams. [more]
what‑it‑does viscosity controlling
A kind of polymer (big molecule from repeated subunits) that helps to create beautiful gel-like textures. It's also a texturizer and thickener for oil-in-water emulsions. [more]
what‑it‑does perfuming
The generic term for nice smelling stuff put into cosmetic products so that the end product also smells nice. It is made up of 30 to 50 chemicals on average. [more]
what‑it‑does buffering
An alkaline (high pH, aka basic) material that is used to set the pH of the cosmetic formula to the right value.  [more]
what‑it‑does preservative
what‑it‑does sunscreen
A physical/inorganic sunscreen with pretty broad spectrum (UVB and UVA II, less good at UVA I) protection and good stability. Might leave some whitish tint on the skin, though. [more]
what‑it‑does surfactant/cleansing | emulsifying
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0, 0
A common glycol that improves the freeze-thaw stability of products. It's also a solvent, humectant and to some extent a penetration enhancer. [more]
what‑it‑does exfoliant | buffering
An AHA that comes from citrus fruits. It is usually used as a helper ingredient to adjust the pH of the formula. [more]
what‑it‑does preservative