Twenty Cream Tretinoin 0.025%
Highlights
Skim through
| Ingredient name | what-it-does | irr., com. | ID-Rating |
|---|---|---|---|
| Tretinoin | cell-communicating ingredient | superstar | |
| Purified Water | solvent | ||
| EDTA | chelating | ||
| Propylene Glycol | moisturizer/humectant, solvent | 0, 0 | |
| Tocopherol | antioxidant | 0-3, 0-3 | goodie |
| Butylated Hydroxy Anisole (BHA) | antioxidant, preservative | icky | |
| Isopropyl Palmitate | emollient | 1, 3-4 | |
| Stearyl Alcohol | emollient, viscosity controlling, emulsifying, surfactant/cleansing | 2, 2 | |
| Fragrance | perfuming | icky | |
| Propylparaben | preservative, perfuming | 0, 0 | |
| Polysorbate 60 | emulsifying, surfactant/cleansing | ||
| Beeswax (White Wax) | emollient, viscosity controlling, emulsifying, perfuming | 0, 0-2 | |
| White Petrolatum | emollient | ||
| Butylated Hydroxytoluene (BHT) | antioxidant, preservative | ||
| Polyoxyl 40 Stearate | emulsifying, surfactant/cleansing | ||
| Stearic Acid | emollient, viscosity controlling | 0, 2-3 | |
| Methylparaben | preservative | 0, 0 |
The U Pharmaceuticals Twenty Cream Tretinoin 0.025%Ingredients explained
- Tretinoin (a metabolite of vitamin A) is the gold standard anti-aging ingredient that is also FDA-approved (and it's the only one so far!)
- It's an all around skin issue fixer as it works at the skin cell level and makes your skin cells behave in a healthy and normal way
- It makes the skin less wrinkled, firmer, smoother and tighter, everything you could want from an anti-aging ingredient
- It's also an effective acne treatment. It normalizes keratinization and makes the pores produce less sebum
- It's also a skin lightener though not as effective as gold-standard hydroquinone.
- Side effects with tretinoin are very common. Irritation, skin flaking, redness, and drier skin are usual
- Do not use tretinoin (or any form of retinoids) while pregnant
- To minimize side effects introduce tretinoin slowly into your routine (see more how to use tips in geeky details)
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
An abbreviation that pops up on a lot of ingredient lists. It stands for EthyleneDiamineTetraacetic Acid and it's a famous molecule for being an excellent chelating agent, i.e. a molecule that can bind to metal ions (coming usually from water) and make them harmless in a cosmetic formula. With a chelating agent, cosmetic formulas stay nice longer.
EDTA is an acid molecule and its salt versions are even more often used, such as the super common Disodium EDTA.
- It's a helper ingredient that improves the freeze-thaw stability of products
- It's also a solvent, humectant and to some extent a penetration enhancer
- It has a bad reputation among natural cosmetics advocates but cosmetic scientists and toxicology experts do not agree (read more in the geeky details section)
- Primary fat-soluble antioxidant in our skin
- Significant photoprotection against UVB rays
- Vit C + Vit E work in synergy and provide great photoprotection
- Has emollient properties
- Easy to formulate, stable and relatively inexpensive
It's the acronym for Butylated Hydroxy Anisole. It's a synthetic antioxidant that's used as a preservative.
It's a somewhat controversial ingredient: The U.S. National Institutes of Health says that BHA is "reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals" (source: wikipedia). But, and this is a big but: these experiments were made on animals and BHA was used in high doses as part of their diet. There is no evidence that the same is true when used in tiny amounts in cosmetics products. So you probably have nothing to worry about, but if you are a better safe than sorry type there are plenty of nice products without BHA to choose from. :)
A clear, colorless emollient ester (oily liquid from isopropyl alcohol + palmitic acid) that makes the skin nice and smooth. It has very good spreading properties and gives a silky touch to the products.
A handy multi-tasker, white to light yellowish oil-loving wax that works very well in oil-in-water emulsions. It makes your skin feel nice and smooth (emollient), stabilizes oil-water mixes and gives body to them.
Oh, and one more thing: it's a so-called fatty alcohol - the good, emollient type of alcohol that is non-drying and non-irritating. It is often mixed with fellow fatty alcohol, Cetyl Alcohol, and the mixture is called Cetearyl Alcohol in the ingredient list.
Exactly what it sounds: nice smelling stuff put into cosmetic products so that the end product also smells nice. Fragrance in the US and parfum in the EU is a generic term on the ingredient list that is made up of 30 to 50 chemicals on average (but it can have as much as 200 components!).
If you are someone who likes to know what you put on your face then fragrance is not your best friend - there's no way to know what’s really in it.
Also, if your skin is sensitive, fragrance is again not your best friend. It’s the number one cause of contact allergy to cosmetics. It’s definitely a smart thing to avoid with sensitive skin (and fragrance of any type - natural is just as allergic as synthetic, if not worse!).
A very common type of feared-by-everyone-mostly-without-scientific-reason parabens. It's a cheap, effective and well-tolerated ingredient to make sure the cosmetic formula does not go wrong too soon.
A common little helper ingredient that helps water and oil to mix together, aka emulsifier.
It's the yellow, solid stuff that you probably know from beeswax candles. It's a natural material produced by honey bees to build their honeycomb.
As for skincare, it's used as an emollient and thickening agent. It's super common in lip balms and lipsticks.
The famous Vaseline or Petroleum Jelly. Just like mineral oil, it is also a by-product of refining crude oil, aka petroleum, and it is also a mixture of hydrocarbons but with bigger (C18-90+) carbon chain length.
The unique thing about petrolatum is that it is the most effective occlusive agent known today. While the occlusivity of mineral oil is in the same league as the occlusivity of plant oils, petrolatum is in a league of its own. It sits on top of the skin and hinders so-called transepidermal water loss (TEWL) like nothing else.
This comes in handy healing cracked lips or severely dry skin patches, though overdoing it (i.e. reducing TEWL by more than 40%) is not good as it can create a nice moist place for fungi and bacteria to grow.
As for petrolatum and safety, we can write here pretty much the exact same thing as we have written at mineral oil. There is no evidence whatsoever that cosmetic, USP grade petrolatum is carcinogenic. It also does not absorb into the skin but sits on top of it and that in itself greatly minimises health risks. It also has a long history of safe use, as it was first used as a skincare product more than 100 years ago, in 1872 to be precise.
It is also non-comedogenic, though its pure form is very heavy and greasy so combination and oily skin types might want to avoid it anyway.
Overall, it is the gold-standard occlusive agent known today and a tub of Vaseline comes in handy in any household to heal cracked lips or other severely dry skin patches.
It's the acronym for Butylated Hydroxy Toluene. It's a common synthetic antioxidant that's used as a preservative.
There is some controversy around BHT. It's not a new ingredient, it has been used both as a food and cosmetics additive since the 1970s. Plenty of studies tried to examine if it's a carcinogen or not. This Truth in Aging article details the situation and also writes that all these studies examine BHT when taken orally.
As for cosmetics, the CIR (Cosmetic Ingredient Review) concluded that the amount of BHT used in cosmetic products is low (usually around 0.01-0.1%), it does not penetrate skin far enough to be absorbed into the bloodstream and it is safe to use in cosmetics.
A common water-loving surfactant and emulsifier that helps to keep water and oil mixed nicely together.
A common multi-tasker fatty acid. It makes your skin feel nice and smooth (emollient), gives body to cream type products and helps to stabilize water and oil mixes (aka emulsions).
The most common type of feared-by-everyone-mostly-without-scientific-reason parabens. It's a cheap, effective and well-tolerated ingredient to make sure the cosmetic formula does not go wrong too soon.
Apart from the general controversy around parabens (we wrote about it more here), there is a 2006 in-vitro (made in the lab not on real people) research about methylparaben (MP) showing that when exposed to sunlight, MP treated skin cells suffered more harm than non-MP treated skin cells. The study was not done with real people on real skin but still - using a good sunscreen next to MP containing products is a good idea. (Well, in fact using a sunscreen is always a good idea. :))
You may also want to take a look at...
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | solvent |
| what‑it‑does | chelating |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 0 |
| what‑it‑does | antioxidant |
| irritancy, com. | 0-3, 0-3 |
| what‑it‑does | antioxidant | preservative |
| what‑it‑does | emollient |
| irritancy, com. | 1, 3-4 |
| what‑it‑does | emollient | viscosity controlling | emulsifying | surfactant/cleansing |
| irritancy, com. | 2, 2 |
| what‑it‑does | perfuming |
| what‑it‑does | preservative | perfuming |
| irritancy, com. | 0, 0 |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | emollient | viscosity controlling | emulsifying | perfuming |
| irritancy, com. | 0, 0-2 |
| what‑it‑does | emollient |
| what‑it‑does | antioxidant | preservative |
| what‑it‑does | emulsifying | surfactant/cleansing |
| what‑it‑does | emollient | viscosity controlling |
| irritancy, com. | 0, 2-3 |
| what‑it‑does | preservative |
| irritancy, com. | 0, 0 |