Tretinoin 0.05% And Niacinamide 4%
Ingredients overview
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Dermatica Tretinoin 0.05% And Niacinamide 4%Ingredients explained
- Tretinoin (a metabolite of vitamin A) is the gold standard anti-aging ingredient that is also FDA-approved (and it's the only one so far!)
- It's an all around skin issue fixer as it works at the skin cell level and makes your skin cells behave in a healthy and normal way
- It makes the skin less wrinkled, firmer, smoother and tighter, everything you could want from an anti-aging ingredient
- It's also an effective acne treatment. It normalizes keratinization and makes the pores produce less sebum
- It's also a skin lightener though not as effective as gold-standard hydroquinone.
- Side effects with tretinoin are very common. Irritation, skin flaking, redness, and drier skin are usual
- Do not use tretinoin (or any form of retinoids) while pregnant
- To minimize side effects introduce tretinoin slowly into your routine (see more how to use tips in geeky details)
- A multi-functional skincare superstar with several proven benefits for the skin
- Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
- Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
- Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
- Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
- It's a helper ingredient that improves the freeze-thaw stability of products
- It's also a solvent, humectant and to some extent a penetration enhancer
- It has a bad reputation among natural cosmetics advocates but cosmetic scientists and toxicology experts do not agree (read more in the geeky details section)
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
An easy-to-formulate, commonly used, nice to have ingredient that’s also called pro-vitamin B5. As you might guess from the “pro” part, it’s a precursor to vitamin B5 (whose fancy name is pantothenic acid).
Its main job in skincare products is to moisturise the skin. It’s a humectant meaning that it can help the skin to attract water and then hold onto it. There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier.
Another great thing about panthenol is that it has anti-inflammatory and skin protecting abilities. A study shows that it can reduce the irritation caused by less-nice other ingredients (e.g. fragrance, preservatives or chemical sunscreens) in the product.
Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation.
If that wasn’t enough panthenol is also useful in nail and hair care products. A study shows that a nail treatment liquide with 2% panthenol could effectively get into the nail and significantly increase the hydration of it.
As for the hair the hydration effect is also true there. Panthenol might make your hair softer, more elastic and helps to comb your hair more easily.
A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.
A super common, waxy, white, solid stuff that helps water and oil to mix together, gives body to creams and leaves the skin feeling soft and smooth.
Chemically speaking, it is the attachment of a glycerin molecule to the fatty acid called stearic acid. It can be produced from most vegetable oils (in oils three fatty acid molecules are attached to glycerin instead of just one like here) in a pretty simple, "green" process that is similar to soap making. It's readily biodegradable.
It also occurs naturally in our body and is used as a food additive. As cosmetic chemist Colins writes it, "its safety really is beyond any doubt".
A light, velvety, unique skin feel liquid that is a good solvent and also makes the skin feel nice and smooth (aka emollient). It's often used in makeup products mixed with silicones to give shine and slip to the product. It's also great for cleansing dirt and oil from the skin as well as for taking off make-up.
A clear, colorless and odorless, highly volatile (meaning it does not absorb into the skin but evaporates from it) liquid that's used as an emollient. It gives a nice non-oily light skin feel and it can improve the slip of the formula without leaving a tacky residue behind.
It's also popular in make-up products as its volatility makes mascaras and foundations last longer. If that would not be enough, it's also an excellent solvent, and it's a regular not only on the ingredients lists of make-ups but also on makeup removers.
A biodegradable emollient that gives a fresh gliding sensation and a powdery after feel. It works well with all kinds of oils including natural and silicone oils.
Probably the most common silicone of all. It is a polymer (created from repeating subunits) molecule and has different molecular weight and thus different viscosity versions from water-light to thick liquid.
As for skincare, it makes the skin silky smooth, creates a subtle gloss and forms a protective barrier (aka occlusive). Also, works well to fill in fine lines and wrinkles and give skin a plump look (of course that is only temporary, but still, it's nice). There are also scar treatment gels out there using dimethicone as their base ingredient. It helps to soften scars and increase their elasticity.
As for hair care, it is a non-volatile silicone meaning that it stays on the hair rather than evaporates from it and smoothes the hair like no other thing. Depending on your hair type, it can be a bit difficult to wash out and might cause some build-up (btw, this is not true to all silicones, only the non-volatile types).
Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
A helper ingredient that functions as a film-forming polymer (big molecule from repeated subunits).
It usually comes to the formula as part of a thickener-emulsifier trio paired with Polyisobutene and Polysorbate 20. The three togeather have excellent thickening properties with remarkable emulsifying-stabilising abilities. They also have a nice silicone feel with glide-on spreading.
A polymer (big molecule from repeated subunits) that's used as a gloss improver for lipsticks and lipglosses. Its stickiness also helps lip products to stay on longer.
Combined with polyacrylate-13 and polysorbate 20, it forms a very effective tickener-emulsifier trio.
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula.
We don't have description for this ingredient yet.
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version.
According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E.
A type of ceramide that can be found naturally in the upper layer of the skin. Ceramides make up 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated.
We have written way more about ceramides at ceramide 1, so click here to know more.
Ceramides get quite a lot of hype recently and good news: there is a reason for that. But before we go into the details, let's just quickly define what the heck ceramides are:
They are waxy lipids that can be found naturally in the outer layer of the skin (called stratum corneum - SC). And they are there in big amounts! The goopy stuff between our skin cells is called extracellular matrix that consists mainly of lipids. And ceramides are about 50% of those lipids (the other important ones are cholesterol with 25% and fatty acids with 15%).
Ok, so now we know what ceramides are, let's see what they do in our skin: research shows clearly that they play a super important role in keeping the skin barrier healthy and the skin hydrated. If ceramides in the skin are decreased, more water can evaporate from the skin and there is less water remaining in the skin. So ceramides form kind of a "water-proof" protecting layer and make sure that our skin remains nice and hydrated.
Now the question is only this: If we put ceramides all over our face do they work as well as ceramides already naturally in our skin? Well, the answer is probably a no, but they do work to some extent. The BeautyBrains blog made a fantastic article about ceramides and they have listed a couple of examples about studies showing that ceramides - especially when used in certain ratios with cholesterol and fatty acids - do hydrate the skin and can help to repair the skin barrier.
So far we were writing about ceramides in plural. It's because there are lots of different ceramides, a 2014 article writes that currently 12 base classes of ceramides are known with over 340 specific species. Chemically speaking, ceramides are the connection of a fatty acid and a sphingoid base and both parts can have different variations that result in the different types of ceramides.
Our current one, Ceramide 1, or more recently called Ceramide EOP, was the first one that was identified in 1982 and it's a special snowflake. It contains the essential fatty acid, linoleic acid and has a unique structure. It's believed that ceramide 1 plays a "binding role" in the lipid layers of the extracellular matrix. Along with ceramides 4 and 7, they also play a vital role in epidermal integrity and serve as the main storage areas for linoleic acid (a fatty acid that's also very important for barrier repair).
Oh, and one more thing: alkaline pH inhibits enzymes that help ceramide synthesis in our skin. So if you use a soap and you notice your skin is becoming dry, now you know why.
One of the many types of ceramides that can be found naturally in the upper layer of the skin. Ceramides make up about 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. It works even better when combined with its pal, Ceramide 1.
We wrote way more about ceramides at ceramide 1, so click here to know more.
It's a type of lipid, a so-called sphingoid base that can be found naturally in the upper layer of the skin. It's found both in "free-form" and as part of famous skin lipids, ceramides.
There is emerging research about Phytosphingosine that shows that it has antimicrobial and cell-communicating properties and is considered part of the skin's natural defense system.
A 2007 study showed that Phytosphingosine even works against evil acne-causing bacteria, Propionibacterium acnes and shows promise as a complementing active ingredient in treating acne-prone skin thanks to its anti-inflammatory and antimicrobial activities.
A nice one to spot in the ingredient list. :)
It's one of the important lipids that can be found naturally in the outer layer of the skin. About 25% of the goopy stuff between our skin cells consists of cholesterol. Together with ceramides and fatty acids, they play a vital role in having a healthy skin barrier and keeping the skin hydrated.
Apart from being an important skin-identical ingredient, it's also an emollient and stabilizer.
A helper ingredient that's used as a co-emulsifier (meaning next to other emulsifiers in the formula it helps water and oil to mix) and as a stabilization agent for foams. Also, has some antimicrobial activity so it can help to boost the effectiveness of the preservative system.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula. It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.
It’s the - sodium form - cousin of the famous NMF, hyaluronic acid (HA). If HA does not tell you anything we have a super detailed, geeky explanation about it here. The TL; DR version of HA is that it's a huge polymer (big molecule from repeated subunits) found in the skin that acts as a sponge helping the skin to hold onto water, being plump and elastic. HA is famous for its crazy water holding capacity as it can bind up to 1000 times its own weight in water.
As far as skincare goes, sodium hyaluronate and hyaluronic acid are pretty much the same and the two names are used interchangeably. As cosmetic chemist kindofstephen writes on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution".
In spite of this, if you search for "hyaluronic acid vs sodium hyaluronate" you will find on multiple places that sodium hyaluronate is smaller and can penetrate the skin better. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. (We also checked Prospector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight).
What seems to be a true difference, though, is that the salt form is more stable, easier to formulate and cheaper so it pops up more often on the ingredient lists.
If you wanna become a real HA-and-the-skin expert you can read way more about the topic at hyaluronic acid (including penetration-questions, differences between high and low molecular weight versions and a bunch of references to scientific literature).
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| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant |
| what‑it‑does | solvent |
| what‑it‑does | moisturizer/humectant | solvent |
| irritancy, com. | 0, 0 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | soothing | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | emollient | viscosity controlling |
| irritancy, com. | 2, 2 |
| what‑it‑does | emollient | emulsifying |
| irritancy, com. | 0, 1-2 |
| what‑it‑does | emollient | solvent |
| what‑it‑does | emollient | solvent |
| what‑it‑does | solvent | emollient |
| what‑it‑does | emollient |
| irritancy, com. | 0, 1 |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | viscosity controlling |
| what‑it‑does | emulsifying | surfactant/cleansing |
| irritancy, com. | 0, 0 |
| what‑it‑does | viscosity controlling |
| what‑it‑does | preservative |
| what‑it‑does | antioxidant |
| irritancy, com. | 0, 0 |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient | cell-communicating ingredient | anti-acne | antimicrobial/antibacterial |
| what‑it‑does | skin-identical ingredient | emollient |
| irritancy, com. | 0, 0 |
| what‑it‑does | emulsifying |
| what‑it‑does | viscosity controlling |
| what‑it‑does | viscosity controlling |
| irritancy, com. | 0, 1 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |