iS Clinical Pro Heal Serum Advance
iS Clinical

Pro Heal Serum Advance

PRO-HEAL SERUM ADVANCE+ features our scientifically advanced L-ascorbic acid (vitamin C), combined with a superior form of Olive Leaf Extract and pure Vitamins E and A. This powerful formulation significantly increases antioxidant protection while helping improve the appearance of compromised, blemish-prone, and aging skin.
Uploaded by: katballay on 09/02/2018

Ingredients overview

Water/ Aqua/ Eau
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
,
Ascorbic Acid
what‑it‑does antioxidant | skin brightening
Pure Vitamin C. A skincare superstar that is clinically proven to boost collagen production (in 5-20% concentration), fade hyperpigmentation and boost UV protection under sunscreen. Also, it's extremely unstable and hard to formulate. [more]
,
Laureth-4
what‑it‑does emulsifying | surfactant/cleansing
,
Alcohol Denat.
what‑it‑does antimicrobial/antibacterial | solvent | viscosity controlling
Alcohol with some additives to make it unconsumable. It is great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent, and antimicrobial. In large amounts, it can be very drying to the skin. [more]
,
Pentylene Glycol
what‑it‑does solvent | moisturizer/humectant
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent, and a broad spectrum antimicrobial. [more]
,
Propylene Glycol
what‑it‑does moisturizer/humectant | solvent | viscosity controlling
irritancy, com. 0 0
A common glycol that improves the freeze-thaw stability of products. It's also a solvent, humectant and to some extent a penetration enhancer. [more]
,
Olea Europaea (Olive) Leaf Extract, Zinc Sulfate
what‑it‑does antimicrobial/antibacterial
,
Tocopherol
what‑it‑does antioxidant
irritancy, com. 2 2
Pure Vitamin E. Great antioxidant that gives significant photoprotection against UVB rays. Works in synergy with Vitamin C. [more]
, [more]
Polyporus Umbellatus (Mushroom) Extract, Arbutin
what‑it‑does antioxidant | skin brightening
One of the better-known skin brightening agents that's found naturally for example in bearberry. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
,
Bioflavonoids
what‑it‑does soothing
,
Retinol
what‑it‑does cell-communicating ingredient
Vitamin A - the most proven anti-aging ingredient available OTC that can smooth wrinkles and make skin firmer. It might also be useful for acne-prone skin as it normalizes keratinization. [more]
,
Polysorbate 20
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
,
Phenoxyethanol
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
[less]

Highlights

Key Ingredients

Antioxidant: Ascorbic Acid
what‑it‑does antioxidant | skin brightening
Pure Vitamin C. A skincare superstar that is clinically proven to boost collagen production (in 5-20% concentration), fade hyperpigmentation and boost UV protection under sunscreen. Also, it's extremely unstable and hard to formulate. [more]
,
Tocopherol
what‑it‑does antioxidant
irritancy, com. 2 2
Pure Vitamin E. Great antioxidant that gives significant photoprotection against UVB rays. Works in synergy with Vitamin C. [more]
,
Arbutin
what‑it‑does antioxidant | skin brightening
One of the better-known skin brightening agents that's found naturally for example in bearberry. [more]
Cell-communicating ingredient: Retinol
what‑it‑does cell-communicating ingredient
Vitamin A - the most proven anti-aging ingredient available OTC that can smooth wrinkles and make skin firmer. It might also be useful for acne-prone skin as it normalizes keratinization. [more]
Skin brightening: Ascorbic Acid
what‑it‑does antioxidant | skin brightening
Pure Vitamin C. A skincare superstar that is clinically proven to boost collagen production (in 5-20% concentration), fade hyperpigmentation and boost UV protection under sunscreen. Also, it's extremely unstable and hard to formulate. [more]
,
Arbutin
what‑it‑does antioxidant | skin brightening
One of the better-known skin brightening agents that's found naturally for example in bearberry. [more]
Skin-identical ingredient: Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
Soothing: Bioflavonoids
what‑it‑does soothing

Show all ingredients by function

Other Ingredients

Antimicrobial/antibacterial: Alcohol Denat.
what‑it‑does antimicrobial/antibacterial | solvent | viscosity controlling
Alcohol with some additives to make it unconsumable. It is great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent, and antimicrobial. In large amounts, it can be very drying to the skin. [more]
,
Zinc Sulfate
what‑it‑does antimicrobial/antibacterial
Emulsifying: Laureth-4
what‑it‑does emulsifying | surfactant/cleansing
,
Polysorbate 20
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
Moisturizer/humectant: Pentylene Glycol
what‑it‑does solvent | moisturizer/humectant
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent, and a broad spectrum antimicrobial. [more]
,
Propylene Glycol
what‑it‑does moisturizer/humectant | solvent | viscosity controlling
irritancy, com. 0 0
A common glycol that improves the freeze-thaw stability of products. It's also a solvent, humectant and to some extent a penetration enhancer. [more]
,
Glycerin
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
Preservative: Phenoxyethanol
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
Solvent: Water/ Aqua/ Eau
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
,
Alcohol Denat.
what‑it‑does antimicrobial/antibacterial | solvent | viscosity controlling
Alcohol with some additives to make it unconsumable. It is great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent, and antimicrobial. In large amounts, it can be very drying to the skin. [more]
,
Pentylene Glycol
what‑it‑does solvent | moisturizer/humectant
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent, and a broad spectrum antimicrobial. [more]
,
Propylene Glycol
what‑it‑does moisturizer/humectant | solvent | viscosity controlling
irritancy, com. 0 0
A common glycol that improves the freeze-thaw stability of products. It's also a solvent, humectant and to some extent a penetration enhancer. [more]
Surfactant/cleansing: Laureth-4
what‑it‑does emulsifying | surfactant/cleansing
,
Polysorbate 20
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 0 0
It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 
Viscosity controlling: Alcohol Denat.
what‑it‑does antimicrobial/antibacterial | solvent | viscosity controlling
Alcohol with some additives to make it unconsumable. It is great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent, and antimicrobial. In large amounts, it can be very drying to the skin. [more]
,
Propylene Glycol
what‑it‑does moisturizer/humectant | solvent | viscosity controlling
irritancy, com. 0 0
A common glycol that improves the freeze-thaw stability of products. It's also a solvent, humectant and to some extent a penetration enhancer. [more]

Ingredients explained

Also-called: Aqua | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Expand to read more

Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying. 

One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time. 

Ascorbic Acid - superstar
Also-called: Vitamin C, L-ascorbic acid | What-it-does: antioxidant, skin brightening
  • Works best between a concentration of 5-20%
  • Boosts the skin’s own collagen production
  • Fades pigmentation and brown spots
  • If used under sunscreen it boosts its UV protection
  • Extremely unstable and oxidizes very easily in presence of light or air
  • Stable in solutions with water only if pH is less than 3.5 or in waterless formulations
  • Vit E + C work in synergy and provide superb photoprotection
  • Ferulic acid doubles the photoprotection effect of Vit C+E and helps to stabilize Vit C
  • Potent Vit. C serums might cause a slight tingling on sensitive skin
Read all the geeky details about Ascorbic Acid here >>

We don't have description for this ingredient yet.

  • It's a super common and super debated skincare ingredient
  • It has several benefits: great solvent, penetration enhancer, creates cosmetically elegant, light formulas, great astringent and antimicrobial
  • It can be very drying if it's in the first few ingredients on an ingredient list
  • Some experts even think that regular exposure to alcohol damages skin barrier and causes inflammation though it's a debated opinion (read more in geeky details tab)
Read all the geeky details about Alcohol Denat. here >>

A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens. 

What-it-does: moisturizer/humectant, solvent, viscosity controlling | Irritancy: 0 | Comedogenicity: 0
  • It's a helper ingredient that improves the freeze-thaw stability of products
  • It's also a solvent, humectant and to some extent a penetration enhancer
  • It has a bad reputation among natural cosmetics advocates but cosmetic scientists and toxicology experts do not agree (read more in the geeky details section)
Read all the geeky details about Propylene Glycol here >>

Also-called: Olive Leaf

We don't have description for this ingredient yet.

We don't have description for this ingredient yet.

Tocopherol - superstar
Also-called: Vitamin E | What-it-does: antioxidant | Irritancy: 2 | Comedogenicity: 2
  • Primary fat-soluble antioxidant in our skin
  • Significant photoprotection against UVB rays
  • Vit C + Vit E work in synergy and provide great photoprotection
  • Has emollient properties
  • Easy to formulate, stable and relatively inexpensive
Read all the geeky details about Tocopherol here >>

We don't have description for this ingredient yet.

Arbutin - goodie
Also-called: Beta-Arbutin | What-it-does: antioxidant, skin brightening

A pretty well-known and often used ingredient with the magic ability to fade brown spots. It's used traditionally in Japan and can be found naturally in a couple of plants, including the leaves of pear trees, wheat and bearberry

Arbutin seems to work its magic and hinder the pigmentation process at the second step of it. An enzyme called tyrosinase is needed to create melanin (the pigment that causes the brown spots) and while several other skin lightening agents work to inhibit the synthesis of tyrosinase itself (like vitamin C or licorice), arbutin lets tyrosinase be and rather hinders the melanin-forming activity of the enzyme. (So it might be a good idea to combine arbutin with some direct tyrosinase inhibitors for more skin lightening effect.)

Expand to read more

All in all, arbutin is one of the better-known skin brightening agents, that's probably worth a try if pigmentation is an issue for you.

Glycerin - goodie
Also-called: Glycerol | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • Super common, used for more than 50 years
  • Not only a simple moisturizer but plays an important role in keeping the stuff between our skin cells healthy
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

What-it-does: soothing

We don't have description for this ingredient yet.

Retinol - superstar
Also-called: Vitamin A, Form of Retinoids | What-it-does: cell-communicating ingredient
  • Retinol (pure Vitamin A) is probably the most proven anti-aging ingredient available OTC
  • Retinol is not itself active, it has to be converted in the skin to retinoic acid to actually do something
  • Once converted it theoretically has the same effect as all-trans-retinoic acid, aka tretinoin
  • A generally accepted ballpark number is that retinol is 10-to-20 times less potent than retinoic acid
  • It makes skin less wrinkled, smoother, firmer and tighter
  • It might also be helpful for acne prone skin as it normalizes keratinization and makes the pores produce less sebum
  • Possible side effects and irritation are also much less than with retinoic acid
  • Do not use whilst pregnant
Read all the geeky details about Retinol here >>

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 0 | Comedogenicity: 0

It's a common little helper ingredient that helps water and oil to mix together. Also, it can help to increase the solubility of some other ingredients in the formula. 

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

Expand to read more

Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10). 

It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.

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