Melanin Correcting Treatment Serum
Ingredients overview
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Derma Choice Melanin Correcting Treatment SerumIngredients explained
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
We don't have description for this ingredient yet.
Propanediol is a natural alternative for the often used and often bad-mouthed propylene glycol. It's produced sustainably from corn sugar and it's Ecocert approved.
It's quite a multi-tasker: can be used to improve skin moisturization, as a solvent, to boost preservative efficacy or to influence the sensory properties of the end formula.
Sunflower does not need a big intro as you probably use it in the kitchen as cooking oil, or you munch on the seeds as a healthy snack or you adore its big, beautiful yellow flower during the summer - or you do all of these and probably even more. And by even more we mean putting it all over your face as sunflower oil is one of the most commonly used plant oils in skincare.
It’s a real oldie: expressed directly from the seeds, the oil is used not for hundreds but thousands of years. According to The National Sunflower Association, there is evidence that both the plant and its oil were used by American Indians in the area of Arizona and New Mexico about 3000 BC. Do the math: it's more than 5000 years – definitely an oldie.
Our intro did get pretty big after all (sorry for that), so let's get to the point finally: sunflower oil - similar to other plant oils - is a great emollient that makes the skin smooth and nice and helps to keep it hydrated. It also protects the surface of the skin and enhances the damaged or irritated skin barrier. Leslie Bauman notes in Cosmetic Dermatology that one application of sunflower oil significantly speeds up the recovery of the skin barrier within an hour and sustains the results 5 hours after using it.
It's also loaded with fatty acids (mostly linoleic (50-74%) and oleic (14-35%)). The unrefined version (be sure to use that on your skin!) is especially high in linoleic acid that is great even for acne-prone skin. Its comedogen index is 0, meaning that it's pretty much an all skin-type oil.
Truth be told, there are many great plant oils and sunflower oil is definitely one of them.
A superabsorbent polymer (big molecule from repeated subunits) that has crazy water binding abilities. Sometimes its referred to as "waterlock" and can absorb 100 to 1000 times its mass in water.
As for its use in cosmetic products, it is a handy multi-tasker that thickens up water-based formulas and also has some emulsifying and emulsion stabilizing properties.
A type of sugar that's part of a moisturizing trio called Aquaxyl. You can read more about its magic properties at xylitylglucoside.
We don't have description for this ingredient yet.
- It’s the most researched AHA with the most proven skin benefits
- It gently lifts off dead skin cells to reveal newer, fresher, smoother skin
- It can help skin’s own collagen production that results in firmer, younger skin
- It can fade brown spots caused by sun damage or PIH
- Choose a product where you know the concentration and pH value because these two greatly influence effectiveness
- Don’t forget to use your sunscreen (in any case but especially so next to an AHA product)
- Slight stinging or burning with a stronger AHA product is normal
- If your skin is very sensitive, rosacea prone choose rather a BHA or PHA product
An optical isomer of naturally occurring arbutin (or beta-arbutin). Just like its sibling, alpha-arbutin is also a skin-brightening, depigmenting agent.
Researching the difference between the two kinds of arbutin, you can read in multiple places on the internet that alpha-arbutin is stronger in effect. Unfortunately, it's never backed up with a credible source. :( Our own research resulted in conflicting results: a study from 1995 found that alpha-arbutin is 10x as effective on mouse melanoma as beta-arbutin. On the other hand, a more recent study from 2015 found that beta-arbutin is more effective both on mouse melanoma cells and on human melanoma cells (btw, kojic acid was the most effective on human melanoma cells).
None of the studies we could find is in-vivo (made on real people) anyways, so who knows. We think you cannot go wrong with trying both beta- and alpha-arbutin and see if one works better for you than the other.
Aloe Vera is one of today’s magic plants. It does have some very nice properties indeed, though famous dermatologist Leslie Baumann warns us in her book that most of the evidence is anecdotal and the plant might be a bit overhyped.
What research does confirm about Aloe is that it’s a great moisturizer and has several anti-inflammatory (among others contains salicylates, polysaccharides, magnesium lactate and C-glucosyl chromone) as well as some antibacterial components. It also helps wound healing and skin regeneration in general. All in all definitely a goodie.
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product.
It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water.
Once inside the skin, it hydrates, but not from the outside - putting pure water on the skin (hello long baths!) is drying.
One more thing: the water used in cosmetics is purified and deionized (it means that almost all of the mineral ions inside it is removed). Like this, the products can stay more stable over time.
A very common ingredient that can be found in all cell membranes. In cosmetics it's quite the multi-tasker: it's an emollient and water-binding ingredient but it's also an emulsifier and can be used for stabilization purposes. It's also often used to create liposomes.
A derivative of clinically proven, superstar ingredient Azelaic Acid and hydrating amino acid Glycine. Azelaic acid is an awesome ingredient with anti-inflammatory, skin lightening and anti-acne effects, but its insolubility (it's soluble neither in water nor in oil) makes it difficult to use it in a cosmetically elegant and versatile way.
The solution is supposed to be Potassium Azeloyl Diglycinate, at least according to the manufacturer. The derivative is very water soluble, easy to use in nice formulas and inherits all the lovely properties of Azelaic acid. It acts as a skin brightening agent via Tyrosinase (a famous enzyme needed to make melanin) inhibition and also has significant sebum normalizing activity.
Regarding research, we could find two studies where Potassium Azeloyl Diglycinate's name popped up. One study examined the management of rosacea and the other one researched the treatment of melasma. Both were successful (we mean people showed improvement :)) but our Azelaic acid derivative was combined with other actives so it's hard to know what to attribute to this guy only.
Overall, a promising multi-function active that's worth checking out if you have pigmentation-prone, acne-prone or rosacea-prone skin.
- A multi-functional skincare superstar with several proven benefits for the skin
- Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
- Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
- Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
- Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
A very stable and promising form of the skincare superstar, Vitamin C. If you do not know why Vitamin C is such a big deal in skin care, you can catch up here. In short, Vitamin C has three proven magic abilities: antioxidant, collagen booster, and skin brightener. The problem, though, is that it's very unstable, turns brown and becomes ineffective in no time (after a few month) and the cosmetics industry is trying to come up with smart derivatives that are stable and have the magic properties of pure Vitamin C.
Ethyl Ascorbic Acid or EAC for short is an "etherified derivative of ascorbic acid" that consists of vitamin C and an ethyl group bound to the third carbon position. This makes Vitamin C very stable and soluble in both water and oil.
However, for a Vitamin C derivative to work it's not enough just to be stable, they also have to be absorbed into the skin and be converted there to pure Vitamin C. We have good news regarding the absorption: on top of manufacturer claims, there is some data (animal study) demonstrating in can get into the skin, and it seems to be better at it than Ascorbyl Glucoside, another vitamin C derivative.
Regarding conversion, we can cite only a manufacturers claim saying that EAC is metabolized in the skin into pure ascorbic acid (and the ascorbic acid content of EAC is very high - 86,4% - compared to the usual 50-60% Vitamin C content of other derivatives).
As for the three magic abilities of Vitamin C, we again mostly have only the manufacturer's claims, but at least those are very promising. EAC seems to have both an antioxidant and anti-inflammatory effect, and it's claimed to be able to boost the skin's collagen production. The strong point of EAC though is skin brightening. On top of manufacturer claims, there is also clinical in-vivo (tested on real people) data showing that 2% EAC can improve skin tone and whiten the skin.
Overall, Ethyl Ascorbic Acid is a very promising but not a fully proven Vitamin C derivative. It's worth a try, especially if you are after Vitamin C's skin-brightening effects.
A colorless liquid used in small amounts as a so-called masking ingredient, meaning it can hide the natural not-so-nice smell of other cosmetic ingredients. It has a nice rose-like scent and can be found in several essential oils such as rose, neroli or geranium. It also has some antimicrobial activity and can boost the performance of traditional preservatives.
It's one of the active parts of Chamomile that contains about 30% of bisabolol. It's a clear oily fluid that is used in skincare as a nice anti-inflammatory and soothing ingredient.
A chelating agent that helps to preserve cosmetic products by neutralizing the metal ions (especially iron) in the formula (that usually get into there from water). Its special thing is that it also acts as a biostatic and fungistatic agent and remains active even at high pH.
It is often coupled with antimicrobial glycols (such as propanediol) to create a "preservative free preservative system" for cosmetic products.
It’s the most commonly used version of pure vitamin E in cosmetics. You can read all about the pure form here. This one is the so-called esterified version.
According to famous dermatologist, Leslie Baumann while tocopheryl acetate is more stable and has a longer shelf life, it’s also more poorly absorbed by the skin and may not have the same awesome photoprotective effects as pure Vit E.
Though its name says acid, it's not really an exfoliant. It's a plant extract with some antioxidant properties. Its main thing in cosmetic products is to neutralize the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. It's a natural alternative to sometimes bad-mouthed chelating agents, EDTAs.
It’s a handy multi-tasking ingredient that gives the skin a nice, soft feel. At the same time, it also boosts the effectiveness of other preservatives, such as the nowadays super commonly used phenoxyethanol.
The blend of these two (caprylyl glycol + phenoxyethanol) is called Optiphen, which not only helps to keep your cosmetics free from nasty things for a long time but also gives a good feel to the finished product. It's a popular duo.
A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular.
It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.
It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic.
Other than having a good safety profile and being quite gentle to the skin it has some other advantages too. It can be used in many types of formulations as it has great thermal stability (can be heated up to 85°C) and works on a wide range of pH levels (ph 3-10).
It’s often used together with ethylhexylglycerin as it nicely improves the preservative activity of phenoxyethanol.
It's one of those things that help your cosmetics not to go wrong too soon, aka a preservative. It can be naturally found in fruits and teas but can also be made synthetically.
No matter the origin, in small amounts (up to 1%) it’s a nice, gentle preservative. Has to be combined with some other nice preservatives, like potassium sorbate to be broad spectrum enough.
In high amounts, it can be a skin irritant, but don’t worry, it’s never used in high amounts.
A glycerin and lauric acid derived multi-functional ingredient that works as a co-emulsifier (helps water and oil to mix together next to other emulsifiers), emollient (makes skin nice and smooth) and anti-microbial agent (preservative booster). It also has some thickening and refatting properties in cleansing formulas.
We don't have description for this ingredient yet.
You might know licorice as a sweet treat from your childhood, but it's actually a legume that grows around the Mediterranean Sea, the Middle East, central and southern Russia. It's sweet and yellow and not only used for licorice all sorts but it's also a skincare superstar thanks to two magic properties:
Nr. 1 magic property is that it has skin-lightening or to say it another way depigmenting properties. The most active part is called glabridin. The topical application (meaning when you put it on your face) of 0.5% glabridin was shown to inhibit UVB caused pigmentation of guinea pigs. Another study even suggested that licorice is more effective than the gold standard skin-lightening agent hydroquinone. All in all, licorice is considered to be one of the safest skin lightening agents with the fewest side effects.
There is just one catch regarding glabridin and licorice: the amount of glabridin in commercial licorice extracts can vary a lot. We have seen extracts with only 4% glabridin as well as 40% glabridin. The latter one is a very-very expensive ingredient, so if you are after the depigmenting properties try to choose a product that boasts its high-quality licorice extract.
Nr. 2 magic property is that licorice is a potent anti-inflammatory. Glabridin has also some soothing properties but the main active anti-inflammatory component is glycyrrhizin. It’s used to treat several skin diseases that are connected to inflammation including atopic dermatitis, rosacea or eczema.
Oh, and one more thing: glabridin seems to be also an antioxidant, which is just one more reason to be happy about licorice root extract on an ingredient list.
Bottom line: Licorice is a great skincare ingredient with significant depigmenting, anti-inflammatory and even some antioxidant properties. Be happy if it's on the ingredient list. :)
A semi-essential (infants cannot synthesize it, but adults can) amino acid that is one of the primary building blocks of hair keratin and skin collagen. It's a natural moisturizing factor, a skin hydrator and might also help to speed up wound healing.
Arginine usually has a positive charge (cationic) that makes it substantive to skin and hair (those are more negatively charged surfaces) and an excellent film former. Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs.
Super common soothing ingredient. It can be found naturally in the roots & leaves of the comfrey plant, but more often than not what's in the cosmetic products is produced synthetically.
It's not only soothing but it' also skin-softening and protecting and can promote wound healing.
The neutralized form of gluconic acid. It's a great ingredient to neutralize metal (especially iron and copper) ions in a cosmetic product. This helps to prevent discoloration of the formula over time or rancidity of cosmetic oils. It can also be a pH regulator and a humectant (helps skin to cling onto water).
It's also used in oral care products where it reduces the bitterness of other ingredients. And it's natural, both Ecocert and Cosmos approved. (source: manufacturer info)
One of the many types of ceramides that can be found naturally in the upper layer of the skin. Ceramides make up about 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. It works even better when combined with its pal, Ceramide 1.
We wrote way more about ceramides at ceramide 1, so click here to know more.
A type of ceramide that can be found naturally in the upper layer of the skin. Ceramides make up 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated.
We have written way more about ceramides at ceramide 1, so click here to know more.
Ceramides get quite a lot of hype recently and good news: there is a reason for that. But before we go into the details, let's just quickly define what the heck ceramides are:
They are waxy lipids that can be found naturally in the outer layer of the skin (called stratum corneum - SC). And they are there in big amounts! The goopy stuff between our skin cells is called extracellular matrix that consists mainly of lipids. And ceramides are about 50% of those lipids (the other important ones are cholesterol with 25% and fatty acids with 15%).
Ok, so now we know what ceramides are, let's see what they do in our skin: research shows clearly that they play a super important role in keeping the skin barrier healthy and the skin hydrated. If ceramides in the skin are decreased, more water can evaporate from the skin and there is less water remaining in the skin. So ceramides form kind of a "water-proof" protecting layer and make sure that our skin remains nice and hydrated.
Now the question is only this: If we put ceramides all over our face do they work as well as ceramides already naturally in our skin? Well, the answer is probably a no, but they do work to some extent. The BeautyBrains blog made a fantastic article about ceramides and they have listed a couple of examples about studies showing that ceramides - especially when used in certain ratios with cholesterol and fatty acids - do hydrate the skin and can help to repair the skin barrier.
So far we were writing about ceramides in plural. It's because there are lots of different ceramides, a 2014 article writes that currently 12 base classes of ceramides are known with over 340 specific species. Chemically speaking, ceramides are the connection of a fatty acid and a sphingoid base and both parts can have different variations that result in the different types of ceramides.
Our current one, Ceramide 1, or more recently called Ceramide EOP, was the first one that was identified in 1982 and it's a special snowflake. It contains the essential fatty acid, linoleic acid and has a unique structure. It's believed that ceramide 1 plays a "binding role" in the lipid layers of the extracellular matrix. Along with ceramides 4 and 7, they also play a vital role in epidermal integrity and serve as the main storage areas for linoleic acid (a fatty acid that's also very important for barrier repair).
Oh, and one more thing: alkaline pH inhibits enzymes that help ceramide synthesis in our skin. So if you use a soap and you notice your skin is becoming dry, now you know why.
It's a type of lipid, a so-called sphingoid base that can be found naturally in the upper layer of the skin. It's found both in "free-form" and as part of famous skin lipids, ceramides.
There is emerging research about Phytosphingosine that shows that it has antimicrobial and cell-communicating properties and is considered part of the skin's natural defense system.
A 2007 study showed that Phytosphingosine even works against evil acne-causing bacteria, Propionibacterium acnes and shows promise as a complementing active ingredient in treating acne-prone skin thanks to its anti-inflammatory and antimicrobial activities.
A nice one to spot in the ingredient list. :)
It's one of the important lipids that can be found naturally in the outer layer of the skin. About 25% of the goopy stuff between our skin cells consists of cholesterol. Together with ceramides and fatty acids, they play a vital role in having a healthy skin barrier and keeping the skin hydrated.
Apart from being an important skin-identical ingredient, it's also an emollient and stabilizer.
A helper ingredient that's used as a co-emulsifier (meaning next to other emulsifiers in the formula it helps water and oil to mix) and as a stabilization agent for foams. Also, has some antimicrobial activity so it can help to boost the effectiveness of the preservative system.
A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula. It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
It's one of the most commonly used thickeners and emulsion stabilizers. If the product is too runny, a little xanthan gum will make it more gel-like. Used alone, it can make the formula sticky and it is a good team player so it is usually combined with other thickeners and so-called rheology modifiers (helper ingredients that adjust the flow and thus the feel of the formula). The typical use level of Xantha Gum is below 1%, it is usually in the 0.1-0.5% range.
Btw, Xanthan gum is all natural, a chain of sugar molecules (polysaccharide) produced from individual sugar molecules (glucose and sucrose) via fermentation. It’s approved by Ecocert and also used in the food industry (E415).
A really famous peptide that is part of Matrixyl 3000, the most sold peptide complex in the word. Before we go and find out what the big deal with Matrixyl 3000 is, let's just focus on Palmitoyl Tripeptide-1 itself for a bit.
It's a small three amino acid (they are the building blocks of all proteins) peptide with the amino sequence of glycine-histidine-lysine, or GHK. GHK is attached to palmitic acid (a fatty acid) to increase oil solubility and skin penetration.
The GHK part is the important one as it's a type I collagen fragment. When collagen naturally breaks down in the skin, the resulting peptide fragments signal to the skin that it should get to work and create some nice, new collagen. Adding in collagen fragment peptides, like GHK, might trick the skin into thinking that collagen has broken down and it's time to create some more.
Therefore, Palmitoyl Tripeptide-1 is believed to be able to stimulate collagen production in the skin, and more collagen means fewer wrinkles and younger looking skin.
In Matrixyl 3000, Palmitoyl Tripeptide-1 is coupled with Palmitoyl Tetrapeptide-7 and the duo works in synergy to reduce wrinkles and give younger looking skin. According to the manufacturer's in-vivo (made on real people) test, applying 3% Matrixyl 3000 twice a day for 2 months resulted in all of the following things:
- 39.4% reduction in surface occupied by deep wrinkles
- 32.9% reduction in main wrinkle density
- 19.9% reduction in main wrinkle average depth
- 16% improvement in roughness
- 16.2% in lifting effect
- 5.5% improvement in elasticity
- 15.5% improvement in skin tone
Manufacturer results, of course, always have to be taken with a pinch of salt, but if you like peptides, the Matryxil 3000 duo is one of the best-proven and most well-known ones and it's something that is worth trying.
It's the triglyceride of behenic acid that works as a thickening or gelling agent, as a compacting agent for pressed powders, and improves heat stability of emulsions.
A vegetable origin (coconut/palm kernel oil, glucose) cleansing agent that gives moderate to high stable foam. It's also biodegradable and mild to the skin.
A multi-functional, silky feeling helper ingredient that can do quite many things. It's used as an emulsion stabilizer, solvent and a broad spectrum antimicrobial. According to manufacturer info, it's also a moisturizer and helps to make the product feel great on the skin. It works synergistically with preservatives and helps to improve water-resistance of sunscreens.
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| what‑it‑does | solvent |
| what‑it‑does | skin brightening | soothing |
| what‑it‑does | emollient |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | emollient |
| irritancy, com. | 0, 0 |
| what‑it‑does | viscosity controlling |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | surfactant/cleansing | emulsifying | perfuming |
| irritancy, com. | 3, 1 |
| what‑it‑does | exfoliant | buffering |
| what‑it‑does | antioxidant | skin brightening |
| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | solvent |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | skin brightening | anti-acne | soothing |
| what‑it‑does | emulsifying |
| what‑it‑does | cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant |
| what‑it‑does | antioxidant | skin brightening |
| what‑it‑does | soothing |
| what‑it‑does | chelating |
| what‑it‑does | antioxidant |
| irritancy, com. | 0, 0 |
| what‑it‑does | chelating |
| what‑it‑does | moisturizer/humectant | emollient |
| what‑it‑does | emollient |
| what‑it‑does | preservative |
| what‑it‑does | preservative | perfuming | solvent | viscosity controlling |
| what‑it‑does | emollient | emulsifying |
| what‑it‑does | soothing | skin brightening |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | soothing |
| irritancy, com. | 0, 0 |
| what‑it‑does | chelating | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient |
| what‑it‑does | skin-identical ingredient | cell-communicating ingredient | anti-acne | antimicrobial/antibacterial |
| what‑it‑does | skin-identical ingredient | emollient |
| irritancy, com. | 0, 0 |
| what‑it‑does | emulsifying |
| what‑it‑does | viscosity controlling |
| irritancy, com. | 0, 1 |
| what‑it‑does | viscosity controlling |
| what‑it‑does | viscosity controlling |
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | emollient |
| what‑it‑does | surfactant/cleansing |
| what‑it‑does | solvent | moisturizer/humectant |
| what‑it‑does | antioxidant | perfuming |