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Differin 0.1% Adapalene Gel

0.1% Adapalene Gel

Differin cream and gel are both prescription-only medicines that are applied directly to the skin, making differin a great choice for people who cannot or who do not wish to take oral antibiotics. The active ingredient, adalpalene, is effective at reducing inflammation, helping to improve the appearance of blackheads, whiteheads, and pustules on the skin. Differin once daily cream and gel are manufactured by galderma and are available in 45-gram tubes for mild to moderate acute acne. Most people will notice an improvement in their skin in just a few weeks. However, differin must be used daily for a full 3 months.
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Differin 0.1% Adapalene Gel
Ingredients explained

Adapalene (0.1%) - superstar
Also-called: Form of Retinoids | What-it-does: cell-communicating ingredient, anti-acne

We don't have description for this ingredient yet.

What-it-does: viscosity controlling, emulsion stabilising | Irritancy: 0 | Comedogenicity: 1

A big molecule created from repeated subunits (a polymer of acrylic acid) that magically converts a liquid into a nice gel formula.  It usually has to be neutralized with a base (such as sodium hydroxide) for the thickening to occur and it creates viscous, clear gels that also feel nice and non-tacky on the skin. No wonder, it is a very popular and common ingredient. Typically used at 1% or less in most formulations.

This ingredient name is not according to the INCI-standard. :( What, why?!

What-it-does: emollient, emulsifying

A mild, corn-sugar derived, oil-loving emulsifier that helps oil and water to mix nicely together. It is safe for sensitive skin or eye-care formulations and gives a light, satiny after-feel. It is often used together with its water-loving buddy Peg-20 Methyl Glucose Sesquistearate.

Glycerol (E422) - superstar
Also-called: Glycerin | What-it-does: skin-identical ingredient, moisturizer/humectant | Irritancy: 0 | Comedogenicity: 0
  • A natural moisturizer that’s also in our skin
  • A super common, safe, effective and cheap molecule used for more than 50 years
  • Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
  • Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
  • High-glycerin moisturizers are awesome for treating severely dry skin
Read all the geeky details about Glycerin here >>

This ingredient name is not according to the INCI-standard. :( What, why?!

Squalene - goodie

Squalene is an oily liquid that originally comes from shark liver but luckily it can also be found in a couple of plant oils. Olive (0.6%), peanut (0.1%) and pumpkin (0.35%) oils contain it, though not in huge amounts. 

What contains more of it, is the sebum (the oily stuff) that our skin produces. About 13% of human sebum is squalene, which means that it’s an important skin-identical ingredient and NMF (natural moisturizing factor)

What-it-does: preservative | Irritancy: 0 | Comedogenicity: 0

The most common type of feared-by-everyone-mostly-without-scientific-reason parabens. It's a cheap, effective and well-tolerated ingredient to make sure the cosmetic formula does not go wrong too soon

Apart from the general controversy around parabens (we wrote about it more here), there is a 2006 in-vitro (made in the lab not on real people) research about methylparaben (MP) showing that when exposed to sunlight, MP treated skin cells suffered more harm than non-MP treated skin cells. The study was not done with real people on real skin but still - using a good sunscreen next to MP containing products is a good idea. (Well, in fact using a sunscreen is always a good idea. :))

What-it-does: preservative, perfuming | Irritancy: 0 | Comedogenicity: 0

A very common type of feared-by-everyone-mostly-without-scientific-reason parabens. It's a cheap, effective and well-tolerated ingredient to make sure the cosmetic formula does not go wrong too soon.

What-it-does: chelating

Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes.

It is typically used in tiny amounts, around 0.1% or less.

What-it-does: emollient, emulsifying

A mild, corn-sugar derived, oil-loving emulsifier that helps oil and water to mix nicely together. It is safe for sensitive skin or eye-care formulations and gives a light, satiny after-feel. It is often used together with its water-loving buddy Peg-20 Methyl Glucose Sesquistearate.

What-it-does: preservative

It’s pretty much the current IT-preservative. It’s safe and gentle, but even more importantly, it’s not a feared-by-everyone-mostly-without-scientific-reason paraben.

It’s not something new: it was introduced around 1950 and today it can be used up to 1% worldwide. It can be found in nature - in green tea - but the version used in cosmetics is synthetic. 

What-it-does: emollient | Irritancy: 0 | Comedogenicity: 0

Cyclomethicone is not one type of silicone, but a whole mixture of them: it's a mix of specific chain length (4 to 7) cyclic structured silicone molecules. (There seems to be a confusion on the internet whether Cyclomethicone and Cyclopentasiloxane are the same. They are not the same, but Cyclopentasiloxane is part of the mixture that makes up Cyclomethicone). 

All the silicones in the Cyclomethicone mixture are volatile, meaning they evaporate from the skin or hair rather than stay on it. This means that Cyclomethicone has a light skin feel with none-to-minimal after-feel.  It also makes the formulas easy to spread and has nice emollient properties.

Also-called: lye | What-it-does: buffering

The unfancy name for it is lye. It’s a solid white stuff that’s very alkaline and used in small amounts to adjust the pH of the product and make it just right. 

For example, in case of AHA or BHA exfoliants, the right pH is super-duper important, and pH adjusters like sodium hydroxide are needed.  

Also-called: Aqua;Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

You may also want to take a look at...

what‑it‑does cell-communicating ingredient | anti-acne
what‑it‑does viscosity controlling
irritancy, com. 0, 1
A handy white powder that magically converts a liquid into a nice gel formula. [more]
what‑it‑does emollient | emulsifying
A mild, corn-sugar derived, oil-loving emulsifier that helps oil and water to mix nicely together. [more]
what‑it‑does skin-identical ingredient | moisturizer/humectant
irritancy, com. 0, 0
A real oldie but a goodie. Great natural moisturizer and skin-identical ingredient that plays an important role in skin hydration and general skin health. [more]
what‑it‑does skin-identical ingredient | antioxidant | emollient
Squalene is an oily liquid that originally comes from shark liver but luckily it can also be found in a couple of plant oils. Olive (0.6%), peanut (0.1%) and pumpkin (0.35%) oils contain it, though not in huge amounts. What contains more of it, is the sebum (the oily stuff) that our skin produces. [more]
what‑it‑does preservative
irritancy, com. 0, 0
The most common type of feared-by-everyone-mostly-without-scientific-reason parabens. It's a cheap, effective and well-tolerated ingredient to make sure the cosmetic formula does not go wrong too soon.  Apart from the general controversy around parabens (we wrote about it more here), there is a 2006 in-vitro (made in the lab not on real people) research about methylparaben (MP) sho [more]
what‑it‑does preservative | perfuming
irritancy, com. 0, 0
A very common type of feared-by-everyone-mostly-without-scientific-reason parabens. It's a cheap, effective and well-tolerated ingredient to make sure the cosmetic formula does not go wrong too soon. [more]
what‑it‑does chelating
Super common little helper ingredient that helps products to remain nice and stable for a longer time. It does so by neutralizing the metal ions in the formula (that usually get into there from water) that would otherwise cause some not so nice changes. [more]
what‑it‑does emollient | emulsifying
A mild, corn-sugar derived, oil-loving emulsifier that helps oil and water to mix nicely together. [more]
what‑it‑does preservative
Pretty much the current IT-preservative. It’s safe and gentle, and can be used up to 1% worldwide. [more]
what‑it‑does emollient
irritancy, com. 0, 0
A mixture of 4 to 7 chain length cyclic silicones. It's a light, volatile ingredient that gives skin or hair a smooth feel and has emollient properties. [more]
what‑it‑does buffering
Lye - A solid white stuff that’s very alkaline and used in small amount to adjust the pH of the product.  [more]
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]