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Apoteka Dona Hidrofilni Krem Sa Tretinoinom 0.05%

Hidrofilni Krem Sa Tretinoinom 0.05%

Tretinoin 0.05% NRF 11.100.
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Ingredients overview

Warning: This ingredient list belongs to a topical product regulated as medicine and uses different ingredient listing rules than regular cosmetics. Read here for more detail.

Apoteka Dona Hidrofilni Krem Sa Tretinoinom 0.05%
Ingredients explained

Tretinoin (0.05%) - superstar
Also-called: All-Trans-Retinoic Acid, Form of Retinoids | What-it-does: cell-communicating ingredient
  • Tretinoin (a metabolite of vitamin A) is the gold standard anti-aging ingredient that is also FDA-approved (and it's the only one so far!)
  • It's an all around skin issue fixer as it works at the skin cell level and makes your skin cells behave in a healthy and normal way
  • It makes the skin less wrinkled, firmer, smoother and tighter, everything you could want from an anti-aging ingredient
  • It's also an effective acne treatment. It normalizes keratinization and makes the pores produce less sebum
  • It's also a skin lightener though not as effective as gold-standard hydroquinone.
  • Side effects with tretinoin are very common. Irritation, skin flaking, redness, and drier skin are usual
  • Do not use tretinoin (or any form of retinoids) while pregnant
  • To minimize side effects introduce tretinoin slowly into your routine (see more how to use tips in geeky details)
Read all the geeky details about Tretinoin here >>

Also-called: Water | What-it-does: solvent

Good old water, aka H2O. The most common skincare ingredient of all. You can usually find it right in the very first spot of the ingredient list, meaning it’s the biggest thing out of all the stuff that makes up the product. 

It’s mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. 

Also-called: Petroleum jelly, Vaseline | What-it-does: emollient

The famous Vaseline or Petroleum Jelly. Just like mineral oil, it is also a by-product of refining crude oil, aka petroleum, and it is also a mixture of hydrocarbons but with bigger (C18-90+) carbon chain length.

The unique thing about petrolatum is that it is the most effective occlusive agent known today. While the occlusivity of mineral oil is in the same league as the occlusivity of plant oils, petrolatum is in a league of its own. It sits on top of the skin and hinders so-called transepidermal water loss (TEWL) like nothing else.

What-it-does: moisturizer/humectant, solvent | Irritancy: 0 | Comedogenicity: 0
  • It's a helper ingredient that improves the freeze-thaw stability of products
  • It's also a solvent, humectant and to some extent a penetration enhancer
  • It has a bad reputation among natural cosmetics advocates but cosmetic scientists and toxicology experts do not agree (read more in the geeky details section)
Read all the geeky details about Propylene Glycol here >>

What-it-does: emollient

A super common emollient that makes your skin feel nice and smooth. It comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. It’s a nice ingredient that just feels good on the skin, is super well tolerated by every skin type and easy to formulate with. No wonder it’s popular. 

What-it-does: emulsifying, surfactant/cleansing | Irritancy: 3 | Comedogenicity: 2

A common functional ingredient that helps to keep the oil-loving and water-loving ingredients together (emulsifier), stabilizes and thickens the products. 

Chemically speaking, it is ethoxylated Cetearyl alcohol, meaning that some ethylene oxide is added to the fatty alcohol to increase the water-soluble part in the molecule. The result is that the mainly oil soluble, emollient fatty alcohol is converted to an emulsifier molecule that keeps oil and water mixed in creams. The number in the name of Ceteareth emulsifiers refers to the average number of ethylene oxide molecules added and 20 makes a good emulsifier.

What-it-does: emollient, viscosity controlling, emulsion stabilising | Irritancy: 2 | Comedogenicity: 2

A so-called fatty (the good, non-drying kind of) alcohol that does all kinds of things in a skincare product: it makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier). Can be derived from coconut or palm kernel oil.

What-it-does: emulsifying | Irritancy: 2 | Comedogenicity: 3

An oily kind of ingredient that can magically blend with water all by itself. This is called self-emulsifying and SE in its name stands for that.

The difference between "normal" Glyceryl Stearate and this guy is that the SE grade contains a small amount of water-loving soap molecules, such as sodium stearate. This increases Glyceryl Stearate's affinity for water and gives it stronger emulsifying abilities.    

Also-called: Mineral Oil | What-it-does: emollient, solvent | Irritancy: 0 | Comedogenicity: 0-2

The famous or maybe rather infamous mineral oil. The clear oily liquid that is the "cheap by-product" of refining crude oil and the one that gets a lot of heat for its poor provenance. It is a very controversial ingredient with pros and cons and plenty of myths around it. So let us see them:  

The pros of mineral oil
Trust us, if something is used for more than 100 years in cosmetic products, it has advantages. Chemically speaking, cosmetic grade mineral oil is a complex mixture of highly refined saturated hydrocarbons with C15-50 chain length. It is not merely a "by-product" but rather a specifically isolated part of petroleum that is very pure and inert.

It is a great emollient and moisturizer working mainly by occlusivity. Occlusivity is one of the basic mechanisms of how moisturizers work and it means that mineral oil sits on top of the skin and hinders so-called trans-epidermal water loss, i.e water evaporating out of your skin. When compared to heavy-duty plant oil, extra virgin coconut oil, the two of them were equally efficient and safe as moisturizers in treating xerosis, a skin condition connected to very dry skin.

Also-called: Butylated Hydroxy Toluene;BHT | What-it-does: antioxidant, preservative

It's the acronym for Butylated Hydroxy Toluene. It's a common synthetic antioxidant that's used as a preservative.

There is some controversy around BHT. It's not a new ingredient, it has been used both as a food and cosmetics additive since the 1970s. Plenty of studies tried to examine if it's a carcinogen or not. This Truth in Aging article details the situation and also writes that all these studies examine BHT when taken orally.

You may also want to take a look at...

what‑it‑does cell-communicating ingredient
The gold-standard, and only FDA-approved anti-aging active ingredient. It works on the skin cell level and makes your skin cells behave in a healthy and normal way. It's not only an anti-aging miracle but is also an effective acne treatment and skin lightener. [more]
what‑it‑does solvent
Normal (well kind of - it's purified and deionized) water. Usually the main solvent in cosmetic products. [more]
what‑it‑does emollient
The famous Vaseline or Petroleum Jelly. Just like mineral oil, it is also a by-product of refining crude oil, aka petroleum, and it is also a mixture of hydrocarbons but with bigger (C18-90+) carbon chain length.The unique thing about petrolatum is that it is the most effective occlusive agent known today. [more]
what‑it‑does moisturizer/humectant | solvent
irritancy, com. 0, 0
A common glycol that improves the freeze-thaw stability of products. It's also a solvent, humectant and to some extent a penetration enhancer. [more]
what‑it‑does emollient
A very common emollient that makes your skin feel nice and smooth. Comes from coconut oil and glycerin, it’s light-textured, clear, odorless and non-greasy. [more]
what‑it‑does emulsifying | surfactant/cleansing
irritancy, com. 3, 2
A common functional ingredient that helps to keep the oil-loving and water-loving ingredients together (emulsifier), stabilizes and thickens the products.  [more]
what‑it‑does emollient | viscosity controlling
irritancy, com. 2, 2
A fatty (the good, non-drying kind of) alcohol that makes your skin feel smooth and nice (emollient), helps to thicken up products and also helps water and oil to blend (emulsifier).
what‑it‑does emulsifying
irritancy, com. 2, 3
An oily ingredient that can magically blend with water all by itself (called Self Emulsifying). Other than that it’s a nice emollient that gives a smooth and soft appearance to the skin. [more]
what‑it‑does emollient | solvent
irritancy, com. 0, 0-2
A clear, oily liquid that comes from refining crude oil. Even though it is a highly controversial ingredient, the scientific consensus is that it is a safe, non-irritating and effective emollient and moisturizer working mainly by occlusivity. [more]
what‑it‑does antioxidant | preservative
It's the acronym for Butylated Hydroxy Toluene. It's a common synthetic antioxidant that's used as a preservative.There is some controversy around BHT. [more]