A313 Vitamin A Pommade
A313

Vitamin A Pommade

French cult retinoid. 200000 U.I. synthetic vitamin A mixture per 100 g of ointment.
Uploaded by: agar_agar on 27/07/2018

Ingredients overview

Retinyl Acetate
what‑it‑does cell-communicating ingredient
,
Retinyl Propionate
what‑it‑does cell-communicating ingredient
A retinol ester that is a less well-known, but pretty interesting member of the retinoids. Its promise is to give similar anti-aging benefits to retinol but with less negative side effects. [more]
,
Retinyl Palmitate
what‑it‑does cell-communicating ingredient
An ester form of vitamin A (retinol + palmitic acid) that is pretty much the least effective member of the retinoid family. Its anti-aging effects are quite questionable as well as its behavior in the presence of UVA light. (Use it at night if possible!) [more]
,
Peg-4000, Peg 400
what‑it‑does solvent
,
Polysorbate 80
what‑it‑does emulsifying | surfactant/cleansing
A common little helper ingredient that helps water and oil to mix together, aka emulsifier. [more]
[less]
retinol acetate, retinol propionate, retinol palmitate, PPG 4000, PEG 400, polysorbate 80

Highlights

Key Ingredients

Cell-communicating ingredient: Retinyl Acetate
what‑it‑does cell-communicating ingredient
,
Retinyl Propionate
what‑it‑does cell-communicating ingredient
A retinol ester that is a less well-known, but pretty interesting member of the retinoids. Its promise is to give similar anti-aging benefits to retinol but with less negative side effects. [more]
,
Retinyl Palmitate
what‑it‑does cell-communicating ingredient
An ester form of vitamin A (retinol + palmitic acid) that is pretty much the least effective member of the retinoid family. Its anti-aging effects are quite questionable as well as its behavior in the presence of UVA light. (Use it at night if possible!) [more]

Show all ingredients by function

Other Ingredients

Emulsifying: Polysorbate 80
what‑it‑does emulsifying | surfactant/cleansing
A common little helper ingredient that helps water and oil to mix together, aka emulsifier. [more]
Solvent: Peg 400
what‑it‑does solvent
Surfactant/cleansing: Polysorbate 80
what‑it‑does emulsifying | surfactant/cleansing
A common little helper ingredient that helps water and oil to mix together, aka emulsifier. [more]

Ingredients explained

Also-called: Form of Retinoids | What-it-does: cell-communicating ingredient

We don't have description for this ingredient yet.

Also-called: Form of Retinoids, Retinol Ester | What-it-does: cell-communicating ingredient

Retinyl Propionate (RP) is a less well-known, but pretty interesting member of the retinoids, aka the "royal family of skincare". You can read the who's who here but the TL;DR version is that tretinoin is the queen herself (the FDA-proven anti-aging active molecule), retinol is like Prince William (two conversion steps needed to be active) and Retinyl Palmitate is like little Prince George (three conversion steps needed to be active).  

Similar to Retinyl Palmitate, Retinyl Propionate is also a retinol ester with retinol and propionic acid being attached together. This puts our molecule in the place of little Princess Charlotte on the family tree, quite far away from the throne.  However, not all retinol ester molecules are made equal when it comes to being transformed and being effective on the skin.

Expand to read more

As Dr. Fulton (the scientist behind both Retin-A and RP) puts it in his patent paper,  "Other esters of vitamin A obtained from, for example, palmitic acid and acetic acid do not have the therapeutic advantages found with vitamin A propionate ..... Presumably, the [Retinyl Palmitate] molecule is so large, it is not able to transdermally reach the necessary part of the skin for activity. Similarly, vitamin A acetate is too small molecularly and therefore easily recrystallizes from any solution.....vitamin A propionate is the appropriate molecular weight and configuration to both remain in a stable solution and to be transdermally delivered to a site where it is active." So while the effectiveness of other retinol esters is highly questionable, Retinyl Propionate seems to be the most effective retinol ester molecule, and it "unexpectedly provides all the benefits of vitamin A acid but minimizes the negative side effects", at least according to Dr. Fulton, the inventor of the molecule. 

We know what you are thinking! This sounds great and all, but what about some proof? Some backup data not from the inventor himself?  We looked into it and found three studies working with Retinyl Propionate.

In a 2007 study by Dr. Draelos, she references a 12-week, double-blind, placebo-controlled clinical trial that compared the effectiveness of 0.15% retinol with 0.3% Retinyl Propionate. Both actives were effective in reducing the appearance of facial wrinkles and hyperpigmentation and the 0.3% RP worked a bit better. 

Another research that was done by Procter & Gamble combined multiple anti-aging actives including niacinamide, peptides and 0.3% of Retinyl Propionate and they compared this regimen with a 0.02% tretinoin regimen. They found that the cosmetic regimen was tolerated better, worked faster and gave comparable results. All this sounds very promising for RP, however, it is hard to know how much the other actives contributed to the positive results. 

Last, but not least there is a study from 1998 that tested a 0.15% Retinyl Propionate cream and after 24 weeks found no statistically significant difference between the effects of the retinyl propionate cream and the placebo preparation for any of the clinical parameters of skin photoaging. However, after 48 weeks, the 0.15% RP worked wonders for actinic keratoses, a rough, scaly patch caused by UV damage (its name contains actinic, but it is not acne, has nothing to do with it (!)).

So, it seems that the minimum effective dose of Retinyl Propionate is larger than 0.15% which is not surprising given that it has to do three conversion steps to reach the active form, retinoic acid. But 0.3% RP (or more, obvs) seems to be an effective dose, and even though the proof is not as solid as it is for retinol itself, if you are looking for a more gentle alternative, or if you are in the mood for experimentation, Retinyl Propionate looks like a noteworthy alternative and the most promising option among retinol esters.

Also-called: Form of Retinoids | What-it-does: cell-communicating ingredient

It's an ester form of vitamin A (retinol + palmitic acid) that belongs to the "retinoid family". The retinoid family is pretty much the royal family of skincare, with the queen being the FDA-approved anti-aging ingredient tretinoin. Retinol is also a very famous member of the family, but it's like Prince William, two steps away from the throne. Retinyl palmitate will be then little Prince George, quite far (3 steps) away from the throne. 

By steps, we mean metabolic steps. Tretinoin, aka retinoic acid, is the active ingredient our skin cells can understand and retinyl palmitate (RP) has to be converted by our metabolic machinery to actually do something. The conversion is a 3 step one and looks like this:

Expand to read more

retinyl palmitate --> retinol -- > retinaldehyde --> all-trans-retinoic acid

As we wrote in our lengthy retinol description the problem is that the conversion is not terribly effective. The evidence that RP is still an effective anti-aging ingredient is not very strong, in fact, it's weak. Dr. Leslie Baumann in her fantastic Cosmetic Dermatology book writes that RP is topically ineffective

What's more, the anti-aging effectiveness is not the only questionable thing about RP. It also exibits questionable behaviour in the presence of UV light and was the center of a debate between the non-profit group, EWG (whose intentions are no doubt good, but its credibility is often questioned by scientists) and a group of scientists and dermatologists lead by Steven Q. Wang, MD,  director of dermatologic surgery at Memorial-Sloan Kettering Cancer Centre. 

Dr. Leslie Baumann wrote a great review of the debate and summarized the research available about retinyl palmitate here.  It seems that there is a study showing RP being photo protective against UVB rays but there is also a study showing RP causing DNA damage and cytotoxicity in association with UVA. 

We think that the truth lies somewhere in the middle, and we agree with Dr. Baumann's conclusion: "sufficient evidence to establish a causal link between RP and skin cancer has not been produced. Nor, I’m afraid, are there any good reasons to recommend the use of RP". We would add especially during the day!

Bottom line: If you wanna get serious about retinoids, RP is not your ingredient (retinol or tretinoin is!). However, if you use a product that you like and it also contains RP, there is no reason to throw it away. If possible use it at night, just to be on the safe side.

We don't have description for this ingredient yet.

What-it-does: solvent, emulsion stabilising

We don't have description for this ingredient yet.

A common little helper ingredient that helps water and oil to mix together, aka emulsifier. 

The number at the end refers to the oil-loving part and the bigger the number  the more emulsifying power it has. 20 is a weak emulsifier, rather called solubilizer used commonly in toners while 60 and 80 are more common in serums and creams.

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