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Jojoba Oil/​Macadamia Seed Oil Esters



Jojoba Oil/Macadamia Seed Oil Esters is the major component of a skin surface lipid mimetic mixture trade named L22.  

So what the heck is a skin surface lipid mimetic mixture? Let's start with skin surface lipids (SLSs): these are the oily substances that your skin produces (mainly the sebaceous glands, a smaller part comes from the epidermis) to keep the skin nice and moisturized. The main components are fatty acids (FAs), triglycerides, cholesterol, cholesteryl esters, wax esters, and squalene. This mixture has a super important role in keeping the skin barrier healthy. 

So Jojoba Oil/Macadamia Seed Oil Esters is a jojoba and macadamia oil-derived ingredient that contains fatty acids, triglycerides, and wax esters. It comes to the formula with Squalene,  Phytosteryl Macadamiate (botanical sourced version of cholesteryl ester) and Phytosterols (botanical version of cholesterol) in the ratios found in young, healthy adult skin.  

So the main skill of L22 is barrier repair and skin hydration and the manufacturer did several double-blind, vehicle-controlled studies to show it really works. It compared 3% of L22 with 3% of olive oil or 3% of caprylic/capric triglyceride alone or combined with Ceramide 2 in a vehicle. 60 minutes after the application, barrier recovery was by far the best by the L22 + Ceramide 2 (0.1%) combination, followed by L22 alone, and then by Olive + Ceramide 2 and Olive alone. Skin hydration was measured 4 hours after application and again, the L22 + Ceramide 2 combination performed the best followed by L22 alone. 

Another study compared 3% L22 with 3% petrolatum (the gold standard occlusive agent). After 1 hour, they performed similarly both for barrier repair and skin hydration, but after 2 weeks of use and a 1 week regression period, L22 showed significantly better results. 

So the bottom line is: if barrier repair is something that you are interested in, the skin surface lipids of L22 can definitely be worth a try. Even better, if the formula also contains Ceramide 2

Show me some proof

  • Addy, J. E. F. F., Tiffany Oliphant, and Robert Harper. "A botanically derived skin surface lipid mimetic based on the composition of healthy 22-year-old females." J Cosmet Sci 68.1 (2017): 59-67.

Products with Jojoba Oil/​Macadamia Seed Oil Esters

InstaNatural Multivitamin C Serum, Anti-Aging, The Jojoba Company Ultimate Youth Potion Boost Lab Jojoba+ Bio-nourishing Face Oil Brillare Deep Root Hydroil Rationale #2 The Light Crème Skinfix Barrier+ Triple Lipid + Collagen Brightening Eye Treatment Skinfix Lipid-Boost Jelly Skinfix Lipid-Hyaluronate Serum Syrene Aqua Intense Cream Cellular Skincare After Care Balm Char's Effectives! Snow Mushroom Serum For Normal To Very Dry Skin Glow Lab Hydrating Booster Treatment Karam MD Illuminate (all-in-one) Karam MD Illuminating Oil LYMA Serum Skin rocks The Support Oil SkinBetter Hydration Boosting Cream Skinfix Barrier+ Triple Lipid + Collagen + Niacinamide Activating Serum Geek & Gorgeous Happier Barrier LANCER Legacy Youth Treatment MALIN + GOETZ Advanced Renewal Cream Skinfix Eczema+ Dermatitis Face Balm Skinfix Eczema+ Dermatitis Relief Balm For Face + Body SweetSpot Labs Hydrate Ever After Tenei Teinei Deep Hydrating Cream Trilogy CoQ10 Eye Recovery Concentrate Vela Days Oil Infusion Cannacomplex® Fortifying Oil Serum adaptology Dry Spell Serum haruharu Wonder Black Rice Facial Oil Brandefy Silks Triple Lipid Peptide Cream Juice Beauty Stem Cellular Vinifera Replenishing Oil LYMA Cream SENTÉ Dermal Repair Ultra-Nourish Savan Skincare Lightweight Moisturizer SeneGence Nangai Oil Skin doctors Age-Defying Power Oil Skincall Silks Triple Lipid Cream Skinfix Lipid-Boost 360° Eye BIOPHORA Liquid Gold City Beauty Barrier Rescue Firming Night Cream Emma Lewisham Illuminating Face And Body Oil Jeuneora Doe Eyes Jeuneora Renewing Booster La mav Beauty Sleep Mask Patricks Am1 Anti-Aging Moisturizer Skinfix Skinfix Barrier+ Triple Lipid-Peptide Lotion Tru Alchemy Quench Creme Yes To Blueberries Age Refresh Face And Neck Oil Basiclab Aminis Actively Stimulating Night Cream Good Virtues C0. Extra Moisturising Facial Cleanser