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Jojoba Oil/​Macadamia Seed Oil Esters



Jojoba Oil/Macadamia Seed Oil Esters is the major component of a skin surface lipid mimetic mixture trade named L22.  

So what the heck is a skin surface lipid mimetic mixture? Let's start with skin surface lipids (SLSs): these are the oily substances that your skin produces (mainly the sebaceous glands, a smaller part comes from the epidermis) to keep the skin nice and moisturized. The main components are fatty acids (FAs), triglycerides, cholesterol, cholesteryl esters, wax esters, and squalene. This mixture has a super important role in keeping the skin barrier healthy. 

So Jojoba Oil/Macadamia Seed Oil Esters is a jojoba and macadamia oil-derived ingredient that contains fatty acids, triglycerides, and wax esters. It comes to the formula with Squalene,  Phytosteryl Macadamiate (botanical sourced version of cholesteryl ester) and Phytosterols (botanical version of cholesterol) in the ratios found in young, healthy adult skin.  

So the main skill of L22 is barrier repair and skin hydration and the manufacturer did several double-blind, vehicle-controlled studies to show it really works. It compared 3% of L22 with 3% of olive oil or 3% of caprylic/capric triglyceride alone or combined with Ceramide 2 in a vehicle. 60 minutes after the application, barrier recovery was by far the best by the L22 + Ceramide 2 (0.1%) combination, followed by L22 alone, and then by Olive + Ceramide 2 and Olive alone. Skin hydration was measured 4 hours after application and again, the L22 + Ceramide 2 combination performed the best followed by L22 alone. 

Another study compared 3% L22 with 3% petrolatum (the gold standard occlusive agent). After 1 hour, they performed similarly both for barrier repair and skin hydration, but after 2 weeks of use and a 1 week regression period, L22 showed significantly better results. 

So the bottom line is: if barrier repair is something that you are interested in, the skin surface lipids of L22 can definitely be worth a try. Even better, if the formula also contains Ceramide 2

Show me some proof

  • Addy, J. E. F. F., Tiffany Oliphant, and Robert Harper. "A botanically derived skin surface lipid mimetic based on the composition of healthy 22-year-old females." J Cosmet Sci 68.1 (2017): 59-67.

Products with Jojoba Oil/​Macadamia Seed Oil Esters

InstaNatural Multivitamin C Serum, Anti-Aging, The Jojoba Company Ultimate Youth Potion Brillare Deep Root Hydroil Skinfix Lipid-Boost Jelly Skinfix Lipid-Hyaluronate Serum Syrene Aqua Intense Cream Cellular Skincare After Care Balm Glow Lab Hydrating Booster Treatment Karam MD Illuminating Oil SkinBetter Hydration Boosting Cream MALIN + GOETZ Advanced Renewal Cream SweetSpot Labs Hydrate Ever After Vela Days Oil Infusion Cannacomplex® Fortifying Oil Serum haruharu Wonder Black Rice Facial Oil Juice Beauty Stem Cellular Vinifera Replenishing Oil SENTÉ Dermal Repair Ultra-Nourish Savan Skincare Lightweight Moisturizer SeneGence Nangai Oil Skin doctors Age-Defying Power Oil Skincall Silks Triple Lipid Cream Skinfix Lipid-Boost 360° Eye BIOPHORA Liquid Gold Jeuneora Renewing Booster La mav Beauty Sleep Mask Patricks Am1 Anti-Aging Moisturizer Skinfix Skinfix Barrier+ Triple Lipid-Peptide Lotion Yes To Blueberries Age Refresh Face And Neck Oil Good Virtues C0. Extra Moisturising Facial Cleanser Jeuneora ThemGenes — Daily Resculpting Serum Skinfix Dark Spot Corrector Tarte Radiance Drops Arcona Four O'Clock Flower® Hydrator Macaria Sunscreen Spray Recreation Beauty Bondi Beach Vibrant Skin Face Oil With Bakuchiol, Sea Greens And Antioxidants Sanctuary Spa Reverse Wonder Oil Serum Skinna Instant Hydrating And Damage Protecting Cream Nannette de Gaspé Art Of Noir - Baume Noir Face Skinfix Barrier + Lipid-Peptide Cream Skinfix Barrier+ Triple Lipid-Peptide Cream Skinfix Barrier+ Triple Lipid-peptide Cream Skinfood Ageless Hyaluronic Moisturising Cream Glow Lab Age Renew Recovery Night Cream Lipstician Rescuer Youth Booster Hale & Hush Vital Lipid Lotion Lipstician Lip Serum Protector Luzern Laboratories Nuit Retinol Creme Intensive RejuvAus Rich Skin Repair Moisturising Cream - Active Rx Supergoop! Daily Dose Hydra Ceramide Boost + SPF 40 Ultraceuticals Ultimate Bio Repair Moisturiser HydroPeptide Face Lift Advanced Ultra Light Moisturiser