Hydroxypinacolone Retinoate (HPR) is the newest member of the "royal family of skincare" (read who is who in the family here), the retinoid family. The queen of the family is the FDA-approved anti-aging superstar, retinoic acid, aka tretinoin and HPR seems to be a gentle but influential sister princess to the queen.
It's a so-called retinoic acid ester, meaning that it's directly related to retinoic acid. If you've already read our description about retinol or retinyl palmitate, you know that the active ingredient our skin cells can interpret is retinoic acid. Other forms of retinoids have to be converted by our metabolic machinery to do something. That's not the case with HPR. It binds directly to the retinoid receptors of the skin cells to work its skincare magic.
The big promise of HPR is that it's similarly active as retinoic acid (no conversion needed, remember) but without the irritation. According to the manufacturer's tests, 24 hours of an occlusive patch with 0.5% HPR resulted in significantly lower irritation than 0.5% retinol. Also, there was a "dramatic reduction of lines and wrinkles" after applying 0.2% HPR around the eyes twice a day for 14 days.
These results sound sooo promising that we don't blame you if you wanna run out right now and get an HPR formula to slather on your face. But, before you do, you have to know that the info we have about HPR at the moment is mainly from the manufacturer, whose tests may or may not be accurate or properly designed (such as controlled, double-blind and conducted on an appropriate number of people).
As HPR is pretty new there isn't that much independent research we could find yet. We found two Italian studies both examining the efficacy of HPR combined with other things (retinol in both cases, and papain in one of them) for the treatment of acne. Both studies found the formulas effective but they contained other things too, so it's hard to judge how well HPR did. We could not find anything about its anti-aging effectiveness, or any studies dealing with HPR on its own.
Bottom line: We are really happy to see some innovation happening with retinoids, and we think Hydroxypinacolone Retinoate is a super promising rising star, but it’s not fully proven yet. If you are someone who likes to experiment and try out the newest things, grab your running shoes and try some HPR containing serum now. If you like the tried and true however, stick to retinol and tretinoin for now and re-examine the question in a couple of years when (hopefully) more research will be available.
- Giornale italiano di dermatologia e venereologia, 2015 Apr;150(2):143-7., Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres.
- Giornale Italiano di Dermatologia e Venereologia, 2016/03, Efficacy and safety of a 12-month treatment with a combination of hydroxypinacolone retinoate and retinol glycospheres as maintenance therapy in acne patients after oral isotretinoin.