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Hydroxypalmitoyl Sphinganine

Hydroxypalmitoyl Sphinganine

Also-called-like-this: Type of Ceramide


Unlike most other ceramides, this is a tricky one to recognize by name, but Hydroxypalmitoyl Sphinganine is a type of ceramide. The TL;DR version of ceramides is that along with cholesterol and fatty acids, the lipid trio (in a 50%, 25% and 15% ratio) is in the outermost layer of the skin helping to maintain a healthy skin barrier. This means keeping nasty things out, and important things such as water in. We have a more detailed description of ceramides here

So as a ceramide, Hydroxypalmitoyl Sphinganine is a nice skin-identical ingredient that supports a healthy skin barrier. More specifically, a promising in-vitro study on reconstructed human skin shows that applying our molecule helps the skin to make some more ceramides (types 1,2 and 3). Interestingly, the extra ceramide production does not happen in the usual pathway, but the skin seems to process and transform Hydroxypalmitoyl Sphinganine into these other ceramides. 

Clinical, aka made on real people studies, have confirmed that products with Hydroxypalmitoyl Sphinganine improve skin hydration, reduce trans epidermal water loss (the amount of water that evaporates out of the skin), and increase the ceramide content of the skin in people with atopic dermatitis or who are being treated with topical tretinoin. A real goodie in our book. 

Show me some proof

  • Meckfessel, Matthew H., and Staci Brandt. "The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products." Journal of the American Academy of Dermatology 71.1 (2014): 177-184.

Products with Hydroxypalmitoyl Sphinganine

Cetaphil Pro Acne Prone Oil-Free Facial Moisturising Lotion Cetaphil Pro Gentle Body Moisturizer Cetaphil Pro Itch Control Moisturizing Lotion Cetaphil Ultra-Healing Lotion With Ceramides For Dry, Rough, Flaky Skin Lancôme Hydra Zen Nuit Vichy Proeven Brightening Cleansing Foam Differin Oil Absorbing Moisturizer Kiehl’s Micro Dose Retinol La Roche-Posay Kerium DS Cream Shu Uemura Rouge Unlimited Matte Lancôme Visionnaire Nuit Night Cream Helena Rubinstein Prodigy Powercell Youth Grafter The Serum L'Oreal Paris Infallible 8Hr Pro-Gloss La Roche-Posay Effaclar H La Roche-Posay Effaclar H Moisturiser Lancôme Énergie De Vie Day Cream Kiehl’s Kiehl'S Ultra Facial Cream L'Oreal Hydra Specialist L'Oreal Paris Triple Active Night Cream La Roche-Posay Nutritic Lip Balm Galderma Basiderm Oil Control Daily Moisturizer La Roche-Posay Nutritic Lips Vichy Proeven Night Acnecide Daily Moisturiser Spf30 Biotherm Aquasource Hydration Gel Biotherm Aquasource Cream Biotherm Aquasource Gel Kiehl’s Age Defender Power Serum it Cosmetics Confidence In Your Beauty Sleep Night Cream Vichy Nutrilogie 2 Kiehl’s Skin Rescuer Vichy Idéalia Nuit it Cosmetics Hello Results Wrinkle-Reducing Daily Retinol Serum-In-Cream Baxter of California Under Eye Complex Cetaphil Pro Oil Absorbing Moisturizer Spf 30 Kiehl’s Powerful Wrinkle Reducing Eye Cream Proactiv MD Daily Oil Control Moisturizer Spf 30 Biotherm Replumping And Smoothing Lip Balm Helena Rubinstein Hydra Collagenist Mask Kiehl’s Ultra Facial Cream Biotherm Aquasource Cocoon Biotherm Aquasource Night Spa Biotherm Life Plankton Aqua Glow Kerastase Chronologiste Mask Kerastase Chronologiste Masque Intense Regenerant Kiehl’s Ultra Facial Cream Vichy Idéalia Anti-Fatigue Eye Care Biotherm Homme Aquapower Kiehl’s Ultimate Razor Burn & Bump Relief Post Shave Cream