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Hydroxypalmitoyl Sphinganine

Hydroxypalmitoyl Sphinganine

Also-called-like-this: Type of Ceramide


Unlike most other ceramides, this is a tricky one to recognize by name, but Hydroxypalmitoyl Sphinganine is a type of ceramide. The TL;DR version of ceramides is that along with cholesterol and fatty acids, the lipid trio (in a 50%, 25% and 15% ratio) is in the outermost layer of the skin helping to maintain a healthy skin barrier. This means keeping nasty things out, and important things such as water in. We have a more detailed description of ceramides here

So as a ceramide, Hydroxypalmitoyl Sphinganine is a nice skin-identical ingredient that supports a healthy skin barrier. More specifically, a promising in-vitro study on reconstructed human skin shows that applying our molecule helps the skin to make some more ceramides (types 1,2 and 3). Interestingly, the extra ceramide production does not happen in the usual pathway, but the skin seems to process and transform Hydroxypalmitoyl Sphinganine into these other ceramides. 

Clinical, aka made on real people studies, have confirmed that products with Hydroxypalmitoyl Sphinganine improve skin hydration, reduce trans epidermal water loss (the amount of water that evaporates out of the skin), and increase the ceramide content of the skin in people with atopic dermatitis or who are being treated with topical tretinoin. A real goodie in our book. 

Show me some proof

  • Meckfessel, Matthew H., and Staci Brandt. "The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products." Journal of the American Academy of Dermatology 71.1 (2014): 177-184.

Products with Hydroxypalmitoyl Sphinganine

Cetaphil Pro Acne Prone Oil-Free Facial Moisturising Lotion L'Oreal Revitalift Filler Plumping Water-cream L'Oreal Revitalift Micro Hyaluronic Acid, Ceramides Plumping Cream Cetaphil Pro Gentle Body Moisturizer Cetaphil Pro Itch Control Moisturizing Lotion Cetaphil Ultra-Healing Lotion With Ceramides For Dry, Rough, Flaky Skin Mixa Ceramide Deep Moisture Hand Cream Differin Oil Control Moisturizer Broad Spectrum Spf 30 L'Oreal Paris Triple Active Fresh Nachtcrème Lancôme Hydra Zen Nuit Mixa Ceramide Moisture Skin Strengthening Cream Mixa Ceramide Protect Body Lotion Vichy Ideal White Gel Nettoyant Vichy Proeven Brightening Cleansing Foam Biotherm Homme Force Supreme Blue Pro-retinol Anti-aging Serum Kiehl’s Micro Dose Retinol La Roche-Posay Kerium DS Cream Shu Uemura Rouge Unlimited Matte L'Oreal Age Perfect Hydra Nutrition Advanced Skin Repair Serum Lancôme Visionnaire Nuit Night Cream Helena Rubinstein Prodigy Powercell Youth Grafter The Serum Lancôme Hydra Zen Stress-Relieving Moisturising Rich Cream Biotherm Aquasource Hyalu Plump Gel L'Oreal Paris Infallible 8Hr Pro-Gloss La Roche-Posay Effaclar H La Roche-Posay Effaclar H Moisturiser Lancôme Absolue Ultimate Bx Replenishing And Restructuring Serum Lancôme Énergie De Vie Day Cream L'Oreal Hydra Specialist L'Oreal Hydra Total 5 Cuidado Día Humectante L'Oreal Paris Triple Active Night Cream Youth To The People Superfood Skin Drip Smooth + Glow Barrier Serum Galderma Basiderm Oil Control Daily Moisturizer L'Oreal Paris Age Perfect 50+ Wrinkle Defying Renewing Eye Cream La Roche-Posay Nutritic Lips Vichy Proeven Night Acnecide Daily Moisturiser Spf30 BENZACARE Creme Hidratante Diário SPF30+ Benzacare Biotherm Aquasource Hydration Gel La Roche-Posay Nutritic Lip Balm Purifide Daily Moisturiser SPF 30 Biotherm Aquasource Cream Cetaphil Pro Ad Derma Skin Restoring Moisturizer Cetaphil Pro Eczema-prone Skin Restoring Moisturizer Biotherm Aquasource Gel Biotherm Aquasource Hyalu Plump Gel Kiehl’s Age Defender Power Serum it Cosmetics Confidence In Your Beauty Sleep Night Cream Biotherm Aquasource Cica Nutri Cream Vichy Nutrilogie 2