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Acetyl Dipeptide-1 Cetyl Ester

Also-called-like-this: Calmosensine


 A soothing dipeptide (tyrosine + arginine) based molecule that functions as a "messenger of tranquility and muscle relaxation". It works via stimulating the skin nerve cells to release met-enkephalin, which is an opioid (i.e. relaxing, pain-relieving) messenger molecule. 

This means that Acetyl Dipeptide-1 Cetyl Ester can "signal" our skin cells to "relax" and it can instantly decrease skin irritations coming from heat, chemical stinging or mechanical stresses. It is also claimed to be able to prevent the onset of wrinkles and expression lines thanks to its muscle relaxation properties.

Regarding the research, we could find one study that compared the calming effects of our guy with the soothing molecule called 4-T-Butylcyclohexanol. They irritated the skin with Capsaicin (the active in chili peppers) and examined how the test products relieved the burning/stinging sensation. They found that both molecules worked, but 4-t-Butylcyclohexanol worked somewhat better. 

Show me some proof

  • Schoelermann, A. M., et al. "Comparison of skin calming effects of cosmetic products containing 4‐t‐butylcyclohexanol or acetyl dipeptide‐1 cetyl ester on capsaicin‐induced facial stinging in volunteers with sensitive skin." Journal of the European Academy of Dermatology and Venereology 30.S1 (2016): 18-20.

Products with Acetyl Dipeptide-1 Cetyl Ester

Marcelle Newage 8-In-1 Power Serum Beverly Hills MD Lift + Firm Sculpting Cream HSBCC Neck Firming Cream Stripped Calm Down For Face Ahava Beauty Before Age Uplift Night Cream Gundry MD Polyphenol Firm + Sculpt Cream Karine Joncas Collagen SN-8 Skoah. Kontrol Serum Ahava Beauty Before Age Uplift Day Cream Spf20 Farmona Herbal Care Siberian Iris Founder's Formula Centipeda Australian Clay Mask ISOMERS Skincare Shave Cream & Cleanser Optaderm Integrity Facial Lotion Prai Ageless Eye Tight Uplift Serum Absolute Care Vitamin A & E Retinol Face Serum Cellular Skin Rx Stress Recovery Complex Founder's Formula Post-workout Australian Clay Detox Mask For Clear Skin - With Muslin Cleansing Cloth L'Oreal Revitalift Laser Retinol + Niacinamide Pressed Night Cream Optaderm Serenity Facial Serum Plush Bio Triple Hyal 23H La Roche-Posay Toleriane Ultra Dermallergo Sheet Mask La Roche-Posay Toleriane Ultra Dermallergo Sterile Hydrating Mask Plush Bio Healing Manuka Honey Stripped Calm Down Atopalm Real Barrier Extreme Cream La Roche-Posay Toleriane Teint Compact Foundation Sesderma Salises Moisturizing Gel Zelens Z Recovery Intensive Repair Balm Functionalab Redness Reducer Serum ISOMERS Skincare Ultra Firming Neck Care Kiehl’s Micro Dose Retinol La Roche-Posay Toleriane Teint Foundation Fluide La Roche-Posay Toleriane Ultra Eye Cream No7 Line Correcting Booster Serum Optaderm Double Action Cleansing Lotion Skoah. Gold Serum Skoah. Supreme Kream torf tołpa Dermo Face 45+ Relift Eye Cream CadeaVera CV Best Age Festigendes Hals- & Dekolletee Serum ISOMERS Skincare Moisture Cream For Men La Roche-Posay Rosaliac AR Intense Serum La Roche-Posay Toleraine Fond De Teint Crème Allergy-tested La Roche-Posay Toleriane Ultra Soothing Repair Moisturizer Medicube Deep Reviving Peptide Eye Cream Optaderm Revitalize Light Facial Concentrate Skoah. Gold Kream Vichy Dermablend Green Corrector Vichy Dermablend Yellow Corrector Bioderma Cicabio Lotion Spray Feel good beauty The Good Serum