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Acetyl Dipeptide-1 Cetyl Ester

Also-called-like-this: Calmosensine

Official CosIng Information


 A soothing dipeptide (tyrosine + arginine) based molecule that functions as a "messenger of tranquility and muscle relaxation". It works via stimulating the skin nerve cells to release met-enkephalin, which is an opioid (i.e. relaxing, pain-relieving) messenger molecule. 

This means that Acetyl Dipeptide-1 Cetyl Ester can "signal" our skin cells to "relax" and it can instantly decrease skin irritations coming from heat, chemical stinging or mechanical stresses. It is also claimed to be able to prevent the onset of wrinkles and expression lines thanks to its muscle relaxation properties.

Regarding the research, we could find one study that compared the calming effects of our guy with the soothing molecule called 4-T-Butylcyclohexanol. They irritated the skin with Capsaicin (the active in chili peppers) and examined how the test products relieved the burning/stinging sensation. They found that both molecules worked, but 4-t-Butylcyclohexanol worked somewhat better. 

Show me some proof

  • Schoelermann, A. M., et al. "Comparison of skin calming effects of cosmetic products containing 4‐t‐butylcyclohexanol or acetyl dipeptide‐1 cetyl ester on capsaicin‐induced facial stinging in volunteers with sensitive skin." Journal of the European Academy of Dermatology and Venereology 30.S1 (2016): 18-20.

Products with Acetyl Dipeptide-1 Cetyl Ester

Marcelle Newage 8-In-1 Power Serum Beverly Hills MD Lift + Firm Sculpting Cream Ahava Beauty Before Age Uplift Night Cream Ahava Beauty Before Age Uplift Day Cream Spf20 Prai Ageless Eye Tight Uplift Serum Plush Bio Healing Manuka Honey Atopalm Real Barrier Extreme Cream Zelens Z Recovery Intensive Repair Balm La Roche-Posay Toleriane Teint Foundation Fluide La Roche-Posay Toleriane Ultra Eye Cream No7 Line Correcting Booster Serum torf tołpa Dermo Face 45+ Relift Eye Cream La Roche-Posay Rosaliac AR Intense Serum La Roche-Posay Toleriane Ultra Soothing Repair Moisturizer Vichy Dermablend Green Corrector Vichy Dermablend Yellow Corrector Feel good beauty The Good Serum La Roche-Posay Toleriane Toleriane Ultra Fluide La Roche-Posay Toleriane Ultra La Roche-Posay Toleriane Ultra Night Moisturizer Patchology Restoring Night Cloud Masque Rilastil Eye Contour Cream Algenist Elevate Advanced Retinol Serum La Roche-Posay Toleriane Ultra Dermallergo Serum NIOD Neck Elasticity Catalist Prai Platinum Firm & Lift Creme Prai Platinum Firm & Lift Eye Creme Superdrug Optimum Phytofreeze Swiss Ice Wine Eye Cream Swanicoco Golden Time Leap Mask Pack CureCode Soothing Relief Gel La Roche-Posay Toleriane Ultra Fluide Cosmedix Bio-Shape Firming Face Mask Estée Lauder Advanced Night Repair Concentrated Recovery Powerfoil Mask La Roche-Posay Vitamin C10 Serum Biologique Recherche Sérum Matriciel Visage La Roche-Posay Toleriane Ultra Eye Contour torf tołpa Dermo Face 45+ Relift SPF 15 B.Glen Qusome Lift Facial Massage Serum Fresh Black Tea Age-Delay Firming Serum Peter Thomas Roth Firmx Growth Factor Extreme Neuropeptide Serum Algenist Elevate Firming & Lifting Neck Cream Bioderma Cicabio Arnica+ La Roche-Posay Anthelios Sun Intolerance Cream SPF 50+ La Roche-Posay La Roche-Posay Toleriane Ultra Overnight Moisturiser La Roche-Posay Redermic C Anti-Wrinkle Firming Moisturizing Filler For Sensitive Skin Sesderma Salises Facial Moisturizing Gel Cream SkinCeuticals Phyto Corrective Masque Algenist Elevate Firming & Lifting Contouring Eye Cream Beauty Pie Triple Hyaluronic Ha + Peptide Serum Beauty Pie Triple Hyaluronic Acid & Lipopeptide Serum