Super Antioxidant Serum With EGF, Gamma Poly Glutamic Acid, And Aloe Vera
Highlights
Key Ingredients
Skim through
| Ingredient name | what-it-does | irr., com. | ID-Rating |
|---|---|---|---|
| EGF | cell-communicating ingredient | ||
| Gamma-Polyglutamic Acid | moisturizer/humectant | goodie | |
| Aloe Vera | soothing, moisturizer/humectant | goodie | |
| Vitamin C | antioxidant, skin brightening, buffering | superstar | |
| Ferulic Acid | antioxidant, antimicrobial/antibacterial | goodie | |
| Dmae | buffering | ||
| Niacinamide | cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant | superstar | |
| Collagen | moisturizer/humectant | goodie | |
| Glycerin | skin-identical ingredient, moisturizer/humectant | 0, 0 | superstar |
| Jojoba Oil | emollient | 0, 0-2 | goodie |
| Hyaluronic Acid | skin-identical ingredient, moisturizer/humectant | goodie |
JJLabs Skincare Solution Super Antioxidant Serum With EGF, Gamma Poly Glutamic Acid, And Aloe VeraIngredients explained
Sh-Oligopeptide-1 is the famous molecule, which is also called Epidermal Growth Factor or EGF. Chemically speaking, Growth Factors are largish peptides or smallish proteins, or to put it in another way, medium-length amino acid sequences (EGF consists of 53 amino acids). Biologically speaking, Growth Factors are cellular signal molecules that can stimulate cell growth, proliferation, healing and/or differentiation.
There are lots of Growth Factors and EGF is just one of them. The topic of "Growth Factors and skincare" is a big, confusing and controversial one and we will try our best to summarize the story for you, including the pros and the cons.
EGF is a special snowflake when it comes to skincare as it was the first Growth Factor that made its way into cosmetic products and it is also the most common one. The American biochemist, Stanley Cohen discovered EGF and was awarded a Noble prize in 1986 for it. As the Noble prize may signify, the molecule is significant and powerful and directly stimulates the proliferation of epidermal cells.
When it comes to Sh-Oligopeptide-1 in a cosmetic product, it has pretty well-established wound healing and skin renewal properties. It might even do more than that. According to a 2012 study on a serum containing barley bioengineered epidermal growth factor, "clinical evaluations showed statistically significant improvement in the appearance of fine lines and rhytids, skin texture, pore size, and various dyschromatic conditions apparent within the first month of use, and continuing improvement trends for the duration of the study" (which was 3 months).
This all sounds amazing, "give me some EGF Serum", we can hear you say! But as we wrote in the intro, the topic is complex and controversial so here are some of the questions that keep coming up around slathering EGF all over our face.
The first and biggest concern is that if EGF is so good at stimulating cell proliferation, how does it relate to cancer? Is the definition of cancer not "cells proliferating out of control"? Most experts agree on this answer: EGF is mitogenic (= stimulates cell proliferation) but not mutagenic (= does not alter the cell to make it cancerous). If you do not have cancer, you will not get cancer from EGF. However, if you have cancerous cells, EGF will help them to spread, just like it helps healthy cells. So if you have a lot of moles, excessive UV exposure in the past, or if you have any of the skin cancer risk factors, we suggest you should think twice about using EGF products. The same is true if you have psoriasis, a skin disease related to the abnormal growth of epidermal skin cells. You do not want to add fuel to the fire with EGF.
Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin.
Overall, our impression is that EGF is definitely a potent molecule. Some EGF products have a cult-like following adding anecdotal evidence to the clinical studies showing EGF has a beneficial effect on the skin. If you like experimenting, by all means, go ahead (unless you have psoriasis or high skin cancer risk factors), but if you are a better safe than sorry type, stick to daily SPF + a good retinoid product. This duo is still the golden standard of anti-aging.
Are you interested in Growth Factors and skincare? We have some more here:
- Human Fibroblast Conditioned Media - a growth factor cocktail used in some cosmetic products
- Insulin-like growth factor 1, aka sh-Oligopeptide -2 - a pal of EGF composed of 70 amino acids
- Vascular Endothelial Growth Factor, aka Sh-Polypeptide-9 - part of a GF cocktail trade named BIO-Placenta
Aloe Vera is one of today’s magic plants. It does have some very nice properties indeed, though famous dermatologist Leslie Baumann warns us in her book that most of the evidence is anecdotal and the plant might be a bit overhyped.
What research does confirm about Aloe is that it’s a great moisturizer and has several anti-inflammatory (among others contains salicylates, polysaccharides, magnesium lactate and C-glucosyl chromone) as well as some antibacterial components. It also helps wound healing and skin regeneration in general. All in all definitely a goodie.
- Works best between a concentration of 5-20%
- Boosts the skin’s own collagen production
- Fades pigmentation and brown spots
- If used under sunscreen it boosts its UV protection
- Extremely unstable and oxidizes very easily in presence of light or air
- Stable in solutions with water only if pH is less than 3.5 or in waterless formulations
- Vit E + C work in synergy and provide superb photoprotection
- Ferulic acid doubles the photoprotection effect of Vit C+E and helps to stabilize Vit C
- Potent Vit. C serums might cause a slight tingling on sensitive skin
Ferulic Acid (FA) is a goodie that can be found naturally in plant cell walls. There is a lot of it especially in the bran of grasses such as rice, wheat and oats.
FA - whose main job is to be an antioxidant - owes its fame to a 2005 research that discovered that adding in 0.5% FA to a 15% Vitamin C + 1% Vitamin E solution not only stabilizes the highly unstable, divaish Vit C, but it also doubles the photoprotection abilities of the formula.
Couple of other studies show that FA just by itself is also a nice addition to cosmetic formulations: it can penetrate the skin (which is kind of important to do the job) and it has protecting properties against UV caused skin damage.
So if you spot it on the ingredient list be happy about it. :)
We don't have description for this ingredient yet.
- A multi-functional skincare superstar with several proven benefits for the skin
- Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration
- Fades brown spots alone or in combination with amino sugar, acetyl glucosamine
- Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration
- Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis
The big and important protein molecule that usually comes from animal skin such as fish or bovine. The gist of the "collagen in topical skincare" subject is to know that collagen in a jar has nothing to do with wrinkles but everything to do with skin hydration. We have a shiny explanation about this at soluble collagen, so click here to read more >>
- A natural moisturizer that’s also in our skin
- A super common, safe, effective and cheap molecule used for more than 50 years
- Not only a simple moisturizer but knows much more: keeps the skin lipids between our skin cells in a healthy (liquid crystal) state, protects against irritation, helps to restore barrier
- Effective from as low as 3% with even more benefits for dry skin at higher concentrations up to 20-40%
- High-glycerin moisturizers are awesome for treating severely dry skin
Jojoba is a drought resistant evergreen shrub native to South-western North America. It's known and grown for jojoba oil, the golden yellow liquid coming from the seeds (about 50% of the weight of the seeds will be oil).
At first glance, it seems like your average emollient plant oil: it looks like an oil and it's nourishing and moisturizing to the skin but if we dig a bit deeper, it turns out that jojoba oil is really special and unique: technically - or rather chemically - it's not an oil but a wax ester (and calling it an oil is kind of sloppy).
So what the heck is a wax ester and why is that important anyway? Well, to understand what a wax ester is, you first have to know that oils are chemically triglycerides: one glycerin + three fatty acids attached to it. The fatty acids attached to the glycerin vary and thus we have many kinds of oils, but they are all triglycerides. Mother Nature created triglycerides to be easily hydrolyzed (be broken down to a glycerin + 3 fatty acid molecules) and oxidized (the fatty acid is broken down into small parts) - this happens basically when we eat fats or oils and our body generates energy from it.
Mother Nature also created wax esters but for a totally different purpose. Chemically, a wax ester is a fatty acid + a fatty alcohol, one long molecule. Wax esters are on the outer surface of several plant leaves to give them environmental protection. 25-30% of human sebum is also wax esters to give us people environmental protection.
So being a wax ester results in a couple of unique properties: First, jojoba oil is extremely stable. Like crazy stable. Even if you heat it to 370 C (698 F) for 96 hours, it does not budge. (Many plant oils tend to go off pretty quickly). If you have some pure jojoba oil at home, you should be fine using it for years.
Second, jojoba oil is the most similar to human sebum (both being wax esters), and the two are completely miscible. Acne.org has this not fully proven theory that thanks to this, jojoba might be able to "trick" the skin into thinking it has already produced enough sebum, so it might have "skin balancing" properties for oily skin.
Third, jojoba oil moisturizes the skin through a unique dual action: on the one hand, it mixes with sebum and forms a thin, non-greasy, semi-occlusive layer; on the other hand, it absorbs into the skin through pores and hair follicles then diffuses into the intercellular spaces of the outer layer of the skin to make it soft and supple.
On balance, the point is this: in contrast to real plant oils, wax esters were designed by Mother Nature to stay on the surface and form a protective, moisturizing barrier and jojoba oil being a wax ester is uniquely excellent at doing that.
- It’s naturally in our skin and behaves there like a sponge
- It can bind up to 1000 times its own weight in water
- It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only)
- High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin
- Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin)
- Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study)
- Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule
You may also want to take a look at...
| what‑it‑does | cell-communicating ingredient |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | soothing | moisturizer/humectant |
| what‑it‑does | antioxidant | skin brightening | buffering |
| what‑it‑does | antioxidant | antimicrobial/antibacterial |
| what‑it‑does | buffering |
| what‑it‑does | cell-communicating ingredient | skin brightening | anti-acne | moisturizer/humectant |
| what‑it‑does | moisturizer/humectant |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |
| irritancy, com. | 0, 0 |
| what‑it‑does | emollient |
| irritancy, com. | 0, 0-2 |
| what‑it‑does | skin-identical ingredient | moisturizer/humectant |